Anti-IL-2 Antibody (6E81)

Name: Anti-IL-2 Antibody (6E81)
Brand: TargetMol
SKU: TMAY-03743
Rating: 4.5 (1 reviews)

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产品编号 TMAY-03743

Anti-IL-2 Antibody (6E81) 是一种 Mouse 抗体，靶向 IL-2。Anti-IL-2 Antibody (6E81) 可用于 IHC-P。

Anti-IL-2 Antibody (6E81)

还可以

产品编号 TMAY-03743

Anti-IL-2 Antibody (6E81) 是一种 Mouse 抗体，靶向 IL-2。Anti-IL-2 Antibody (6E81) 可用于 IHC-P。

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生物活性

产品描述	Anti-IL-2 Antibody (6E81) is a Mouse antibody targeting IL-2. Anti-IL-2 Antibody (6E81) can be used in IHC-P.
Ig Type	Monoclonal Mouse IgG2b
克隆号	6E81
交叉反应	Rat
验证活性	Immunochemical staining of rat IL2 in rat spleen (from 2 donors) with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections).
应用	IHC-P
推荐剂量	IHC-P: 1:50-1:200
抗体种类	Monoclonal
宿主来源	Mouse
构建方式	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat Interleukin-2 / IL-2 (rR Interleukin-2 / IL-2; TMPY-02457; P17108; Ala21-Gln155). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式	Protein A
性状	Liquid
缓冲液	0.2 μm filtered solution in PBS
研究背景	Interleukin-2, also known as a T-cell growth factor, TCGF, Aldesleukin, and IL2, is a secreted protein that belongs to the IL-2 family. Interleukin-2 / IL-2 was the first interleukin molecule to be discovered. Interleukin-2 / IL-2 molecule was first purified to homogeneity by immunoaffinity chromatography by Kendall Smith and his team at Dartmouth Medical School. Interleukin-2 / IL-2 was also the first cytokine shown to mediate its effects via a specific IL-2 receptor, and it was also the first interleukin to be cloned and expressed from a complementary DNA (cDNA) library. Interleukin-2 / IL-2 was designated number 2 because Smith's data at the time indicated that IL-1, produced by macrophages, facilitates IL-2 production by T lymphocytes (T cells).Interleukin-2 / IL-2 is produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Interleukin-2 / IL-2 is normally produced by the body during an immune response. When environmental substances (molecules or microbes) gain access to the body, these substances (termed antigens) are recognized as foreign by antigen receptors that are expressed on the surface of lymphocytes. Antigen binding to the T cell receptor (TCR) stimulates the secretion of Interleukin-2 / IL-2 and the expression of IL-2 receptors IL-2R. The IL-2 / IL-2R interaction then stimulates the growth, differentiation, and survival of antigen-selected cytotoxic T cells via the activation of the expression of specific genes. Interleukin-2 / IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. The World Reference Standard for Interleukin-2 / IL-2 is produced by the National Institute of Biological Standards and Control in the UK. A recombinant form of Interleukin-2 / IL-2 for clinical use is manufactured by Chiron Corporation with the brand name Proleukin. It has been approved by the Food and Drug Administration (FDA) for the treatment of cancers (malignant melanoma, renal cell cancer), and is in clinical trials for the treatment of chronic viral infections, and as a booster (adjuvant) for vaccines. The use of Interleukin-2 / IL-2 in HIV therapy is ineffective.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

偶联与修饰

偶联	Unconjugated

抗原信息

免疫原	Recombinant Rat Interleukin-2 / IL-2 protein (TMPY-02457)
抗原种属	Rat
研究领域	Neuroinflammation

存储&运输

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式	Shipping with blue ice.