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Anti-Hemojuvelin Antibody (7C766)
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产品编号 TMAY-00783
别名 hemochromatosis type 2 (juvenile)
Anti-Hemojuvelin Antibody (7C766) 是一种 Mouse 抗体，靶向 Hemojuvelin。Anti-Hemojuvelin Antibody (7C766) 可用于 ELISA。
Anti-Hemojuvelin Antibody (7C766)
Anti-Hemojuvelin Antibody (7C766)
还可以产品编号 TMAY-00783 别名 hemochromatosis type 2 (juvenile)
Anti-Hemojuvelin Antibody (7C766) 是一种 Mouse 抗体，靶向 Hemojuvelin。Anti-Hemojuvelin Antibody (7C766) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,684 | 5日内发货 |
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偶联与修饰
抗原信息
| 产品描述 | Anti-Hemojuvelin Antibody (7C766) is a Mouse antibody targeting Hemojuvelin. Anti-Hemojuvelin Antibody (7C766) can be used in ELISA. |
| 别名 | hemochromatosis type 2 (juvenile) |
| Ig Type | Mouse IgG1 |
| 克隆号 | 7C766 |
| 交叉反应 | Human |
| 应用 | |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Hemojuvelin / HFE2 (rh Hemojuvelin / HFE2; TMPY-02833; Q6ZVN8-1; Met1-Ser399). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Hemojuvelin, also known as HFE2, is a membrane-bound and soluble protein that belongs to the repulsive guidance molecule (RGM) family. It is known that RGMs function through Neogenin, a homolog of the Netrin receptor deleted in colon cancer. In mammals, the RGM family consists of three glycoproteins that have discrete expression patterns and functions (RGM-A, RGM-B, and RGM-C). Hemojuvelin is expressed in adult and fetal liver, heart, and skeletal muscle. Hemojuvelin acts as a bone morphogenetic protein (BMP) coreceptor. Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism. It plays a key role in iron metabolism. Hemojuvelin represents the cellular receptor for hepcidin. It may be a component of the signaling pathway that activates hepcidin or it may act as a modulator of hepcidin expression. Defects in hemojuvelin are the cause of hemochromatosis type 2A, also known as juvenile hemochromatosis (JH). |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human Hemojuvelin / HFE2 Protein (TMPY-02833) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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