购物车
- 全部删除
您的购物车当前为空
Anti-GM-CSF/CSF2 Antibody (2Z919)
还可以产品编号 TMAY-00084
Anti-GM-CSF/CSF2 Antibody (2Z919) 是一种 Mouse 抗体，靶向 GM-CSF/CSF2。Anti-GM-CSF/CSF2 Antibody (2Z919) 可用于 ELISA,ELISA(Det)。
Anti-GM-CSF/CSF2 Antibody (2Z919)
Anti-GM-CSF/CSF2 Antibody (2Z919)
还可以产品编号 TMAY-00084
Anti-GM-CSF/CSF2 Antibody (2Z919) 是一种 Mouse 抗体，靶向 GM-CSF/CSF2。Anti-GM-CSF/CSF2 Antibody (2Z919) 可用于 ELISA,ELISA(Det)。
产品信息正在更新中，如果您想购买，请点击大包装&定制按钮.
大包装 & 定制
联系我们获取更多批次信息
资源下载
产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-GM-CSF/CSF2 Antibody (2Z919) is a Mouse antibody targeting GM-CSF/CSF2. Anti-GM-CSF/CSF2 Antibody (2Z919) can be used in ELISA,ELISA(Det). |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 2Z919 |
| 交叉反应 | Human |
| 应用 | ELISA,ELISA(Det) |
| 推荐剂量 | ELISA: 1:1000-1:2000; ELISA(Det): 1:1000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human GM-CSF / CSF2 (rh GM-CSF / CSF2; TMPY-02466; NP_000749.2; Ala 18-Glu 144). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestational tissues synthesise GM-CSF under direction by ovarian steroid hormones and signalling agents originating in male seminal fluid and the conceptus. The pre-implantation embryo, invading placental trophoblast cells and the abundant populations of leukocytes controlling maternal immune tolerance are all subject to GM-CSF regulation. GM-CSF stimulates the differentiation of hematopoietic progenitors to monocytes and neutrophils, and reduces the risk for febrile neutropenia in cancer patients. GM-CSF also has been shown to induce the differentiation of myeloid dendritic cells (DCs) that promote the development of T-helper type 1 (cellular) immune responses in cognate T cells. The active form of the protein is found extracellularly as a homodimer, and the encoding gene is localized to a related gene cluster at chromosome region 5q31 which is known to be associated with 5q-syndrome and acute myelogenous leukemia. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GM-CSF has been utilized in the clinical management of multiple disease processes. Most recently, GM-CSF has been incorporated into the treatment of malignancies as a sole therapy, as well as a vaccine adjuvant. While the benefits of GM-CSF in this arena have been promising, recent reports have suggested the potential for GM-CSF to induce immune suppression and, thus, negatively impact outcomes in the management of cancer patients. GM-CSF deficiency in pregnancy adversely impacts fetal and placental development, as well as progeny viability and growth after birth, highlighting this cytokine as a central maternal determinant of pregnancy outcome with clinical relevance in human fertility.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 其他可选修饰符 | HRP |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Human GM-CSF / CSF2 protein (TMPY-02466) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
SCI 文献
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
评论列表
预览
Related Tags: buy Anti-GM-CSF/CSF2 Antibody (2Z919) | purchase Anti-GM-CSF/CSF2 Antibody (2Z919) | Anti-GM-CSF/CSF2 Antibody (2Z919) cost | order Anti-GM-CSF/CSF2 Antibody (2Z919)
嗨！有任何问题？点我咨询
评论内容