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Anti-CSF3R/G-CSFR Antibody (4I21)
还可以产品编号 TMAY-00481
Anti-CSF3R/G-CSFR Antibody (4I21) 是一种 Mouse 抗体，靶向 CSF3R/G-CSFR。Anti-CSF3R/G-CSFR Antibody (4I21) 可用于 ELISA(Cap),ICC/IF。
Anti-CSF3R/G-CSFR Antibody (4I21)
Anti-CSF3R/G-CSFR Antibody (4I21)
还可以产品编号 TMAY-00481
Anti-CSF3R/G-CSFR Antibody (4I21) 是一种 Mouse 抗体，靶向 CSF3R/G-CSFR。Anti-CSF3R/G-CSFR Antibody (4I21) 可用于 ELISA(Cap),ICC/IF。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CSF3R/G-CSFR Antibody (4I21) is a Mouse antibody targeting CSF3R/G-CSFR. Anti-CSF3R/G-CSFR Antibody (4I21) can be used in ELISA(Cap),ICC/IF. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4I21 |
| 交叉反应 | Human |
| 验证活性 | Confocal immunofluorescence analysis of Human GCSFR in MCF7 cells. Cells were fixed with 4% PFA, permeabilzed with 1% Triton X-100 in PBS, blocked with 10% serum, and incubated with Mouse anti-Human GCSFR monoclonal antibody (1:60). Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-mouse IgG secondary antibody, countstained with Alexa Fluor® 546-conjugated phallotoxins (red) and DAPI (blue). Positive staining was localized to cytoplasm and cytomembrane. |
| 应用 | ELISA(Cap),ICC/IF |
| 推荐剂量 | ICC-IF: 1:20-1:100; ELISA(Cap): 1:250-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human G-CSFR / CD114 (rh G-CSFR / CD114; NP_000751.1Met1-Pro621). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/PE |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human G-CSFR / CD114 protein |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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