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Anti-Angiopoietin-2 Antibody (9V837)
还可以产品编号 TMAY-01063
Anti-Angiopoietin-2 Antibody (9V837) 是一种 Mouse 抗体，靶向 Angiopoietin-2。Anti-Angiopoietin-2 Antibody (9V837) 可用于 ELISA(Cap)。
Anti-Angiopoietin-2 Antibody (9V837)
Anti-Angiopoietin-2 Antibody (9V837)
还可以产品编号 TMAY-01063
Anti-Angiopoietin-2 Antibody (9V837) 是一种 Mouse 抗体，靶向 Angiopoietin-2。Anti-Angiopoietin-2 Antibody (9V837) 可用于 ELISA(Cap)。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Angiopoietin-2 Antibody (9V837) is a Mouse antibody targeting Angiopoietin-2. Anti-Angiopoietin-2 Antibody (9V837) can be used in ELISA(Cap). |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 9V837 |
| 交叉反应 | Human |
| 应用 | ELISA(Cap) |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Angiopoietin-2 (rh Angiopoietin-2; NP_001138.1Met1-Phe496). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine kinase receptor, Tie-2, found primarily on the luminal surface of endothelial cells. ANG-2's role in angiogenesis generally is considered as an antagonist for ANG1, inhibiting ANG1-promoted Tie2 signaling, which is critical for blood vessel maturation and stabilization. ANG-2 modulates angiogenesis in a cooperative manner with another important angiogenic factor, vascular endothelial growth factor A. Genetic studies have revealed that ANG-2 also is critical in lymphangiogenesis during development. ANG-2 has multiple physiologic effects that regulate vascular tone, hormone secretion, tissue growth and neural activity. Several reports indicate that ANG-2 can induce neovascularization in experimental systems due to the expression of different growth factors such as angiopoietin 2, vascular endothelial factor, and its receptor, fibroblast growth factor, platelet derived growth factor, transforming growth factor beta and epidermal growth factor. In addition, ANG-2 is strongly expressed in the vasculature of many tumors and it has been suggested that ANG-2 may act synergistically with other cytokines such as vascular endothelial growth factor to promote tumor-associated Angiogenesis and tumor progression. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human Angiopoietin-2 Protein |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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