首页 工具
登录
Suramin Sodium Salt

Suramin Sodium Salt

产品编号 T2160   CAS 129-46-4
别名: Suramin hexasodium salt, 苏拉明钠, NF-060, BAY-205, 苏拉明钠盐

Suramin sodium salt 是可逆的竞争性蛋白酪氨酸磷酸酶抑制剂。它抑制 IP5K,是抗寄生虫,抗肿瘤和抗血管生成剂。它是sirtuins 的有效抑制剂,也是 SARS-CoV-2 RNA 依赖性 RNA 聚合酶抑制剂。

TargetMol的所有产品和服务仅用于科学研究,不能被用于人体,我们也不向个人提供产品和服务。
Suramin Sodium Salt, CAS 129-46-4
我们的产品含有多种规格,如需了解具体的规格以及价格信息,请联系我们咨询订购,对于大额的订购,我们还有额外的优惠!
产品咨询
产品目录号及名称: Suramin Sodium Salt (T2160)
点击图片重新获取验证码
选择批次  
纯度: 99.97%
纯度: 99.97%
纯度: 99.93%
纯度: 99.8%
纯度: 99.76%
纯度: 97.47%
更多批次查询请联系客服
生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Suramin Sodium is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.
靶点活性 DNA topoisomerase II:5 μM
体外活性 Suramin inhibits cell proliferation and DNA synthesis in cultured HeLa cells. The replication of SV40 DNA is completely abolished by 40 μM suramin. DNA polymerase α is sensitive to lower concentrations of suramin (IC50=8 μM) than is DNA polymerase δ (IC50=36 μM), whereas DNA polymerase β is relatively insensitive to the drug (IC50 of 90 μM)[1]. Suramin is a potent inhibitor of DNA strand exchange and ATPase activities of bacterial RecA proteins. Suramin inhibits RecA-catalysed proteolytic cleavage of the LexA repressor. The mechanism underlying such inhibitory actions of suramin involves its ability to disassemble RecA–single-stranded DNA filaments[2]. Suramin is a potent inhibitor of the nuclear enzyme DNA topoisomerase II. Suramin inhibits purified yeast topoisomerase II with an IC50 of about 5 μM[3].
体内活性 Treatment with suramin shows lower values for pulmonary artery pressure, right ventricular hypertrophy, and distal vessel muscularization on day 21 compared to control rats. Suramin treatment suppresses PA-SMC proliferation and attenuates both the inflammatory response and the deposition of collagen[4].
激酶实验 The ATPase assay is performed in a 10 μL reaction mixture containing 20 mM Tris-HCl (pH 7.5), 1 mM DTT, 8 mM MgCl2, 5 μM M13 circular ssDNA, 2.5 μM RecA from the specified bacterial species and increasing concentrations of suramin. The reaction is initiated by the addition of 2 mM [α-32P]ATP, incubated for 30 min at 37°C and stopped by the addition of 25 mM EDTA[2].
别名 Suramin hexasodium salt, 苏拉明钠, NF-060, BAY-205, 苏拉明钠盐
分子量 1429.15
分子式 C51H34N6Na6O23S6
CAS No. 129-46-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

溶解度

DMSO: 10 mM

( < 1 mg/mL refers to the product slightly soluble or insoluble )

参考文献

1. Jindal HK, et al. Suramin affects DNA synthesis in HeLa cells by inhibition of DNA polymerases. Cancer Res. 1990 Dec 15;50(24):7754-7. 2. Nautiyal A, et al. Suramin is a potent and selective inhibitor of Mycobacterium tuberculosis RecA protein and the SOS response: RecA as a potential target for antibacterial drug discovery. J Antimicrob Chemother. 2014 Jul;69(7):1834-43. 3. Bojanowski K, et al. Suramin is an inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcomacells. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3025-9. 4. Izikki M, et al. The beneficial effect of suramin on monocrotaline-induced pulmonary hypertension in rats. PLoS One. 2013 Oct 15;8(10):e77073. 5. Wan Y, Feng B, You Y, et al. Microglial Displacement of GABAergic Synapses Is a Protective Event during Complex Febrile Seizures[J]. Cell Reports. 2020, 33(5): 108346.

文献引用

1. Wan Y, Feng B, You Y, et al. Microglial Displacement of GABAergic Synapses Is a Protective Event during Complex Febrile Seizures. Cell Reports. 2020, 33(5): 108346
CpCDPK1/TgCDPK1-IN-2 Sulmazole Dehydroemetine MMV688533 (-)-Anonaine Cletoquine hydrochloride Brotianide ZY-19489

相关化合物库

该产品包含在如下化合物库中:
抗癌活性化合物库 DNA 损伤和修复分子库 表观遗传库 抗肺癌化合物库 抗癌临床化合物库 抗感染化合物库 磷酸酶抑制剂化合物库 临床期小分子药物库 NO PAINS 化合物库 抗衰老化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
=
X
X
X
=
X
=
/
g/mol

输入分子式,点击计算,可计算出产品的分子量。

bottom

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Suramin Sodium Salt 129-46-4 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism Microbiology/Virology Parasite Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Phosphatase Suramin phosphatases DNA antiparasitic anti-angiogenic Suramin hexasodium Inhibitor Suramin hexasodium salt IP5K 苏拉明钠 anti-neoplastic inhibit NF-060 BAY-205 protein-tyrosine PTPases antitrypanosomal SARS coronavirus 苏拉明钠盐 inhibitor

 

陶术
生物
TargetMol®中国区唯一合作伙伴
点击进入陶术生物官网陶术生物
联系我们
400-820-0310

上海市静安区江场三路238号8楼