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Suramin Sodium Salt

Suramin Sodium Salt

产品编号 T2160   CAS 129-46-4
别名: 苏拉明钠, BAY-205, Suramin hexasodium salt, 苏拉明钠盐, NF-060

Suramin Sodium Salt (BAY-205) 是可逆的竞争性蛋白酪氨酸磷酸酶抑制剂。它抑制 IP5K,是抗寄生虫,抗肿瘤和抗血管生成剂。它是sirtuins 的有效抑制剂,也是 SARS-CoV-2 RNA 依赖性 RNA 聚合酶抑制剂。

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Suramin Sodium Salt Chemical Structure
Suramin Sodium Salt, CAS 129-46-4
规格 价格/CNY 货期 数量
1 mg ¥ 279 现货
5 mg ¥ 640 现货
10 mg ¥ 939 现货
25 mg ¥ 1,690 现货
50 mg ¥ 2,796 现货
100 mg ¥ 3,940 现货
其他形式的 Suramin Sodium Salt:
产品目录号及名称: Suramin Sodium Salt (T2160)
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纯度: 99.97%
纯度: 99.97%
纯度: 99.93%
纯度: 99.8%
纯度: 99.76%
纯度: 97.47%
更多批次查询请联系客服
生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.
靶点活性 DNA topoisomerase II:5 μM
体外活性 Suramin inhibits cell proliferation and DNA synthesis in cultured HeLa cells. The replication of SV40 DNA is completely abolished by 40 μM suramin. DNA polymerase α is sensitive to lower concentrations of suramin (IC50=8 μM) than is DNA polymerase δ (IC50=36 μM), whereas DNA polymerase β is relatively insensitive to the drug (IC50 of 90 μM)[1]. Suramin is a potent inhibitor of DNA strand exchange and ATPase activities of bacterial RecA proteins. Suramin inhibits RecA-catalysed proteolytic cleavage of the LexA repressor. The mechanism underlying such inhibitory actions of suramin involves its ability to disassemble RecA–single-stranded DNA filaments[2]. Suramin is a potent inhibitor of the nuclear enzyme DNA topoisomerase II. Suramin inhibits purified yeast topoisomerase II with an IC50 of about 5 μM[3].
体内活性 Treatment with suramin shows lower values for pulmonary artery pressure, right ventricular hypertrophy, and distal vessel muscularization on day 21 compared to control rats. Suramin treatment suppresses PA-SMC proliferation and attenuates both the inflammatory response and the deposition of collagen[4].
激酶实验 The ATPase assay is performed in a 10 μL reaction mixture containing 20 mM Tris-HCl (pH 7.5), 1 mM DTT, 8 mM MgCl2, 5 μM M13 circular ssDNA, 2.5 μM RecA from the specified bacterial species and increasing concentrations of suramin. The reaction is initiated by the addition of 2 mM [α-32P]ATP, incubated for 30 min at 37°C and stopped by the addition of 25 mM EDTA[2].
别名 苏拉明钠, BAY-205, Suramin hexasodium salt, 苏拉明钠盐, NF-060
分子量 1429.15
分子式 C51H34N6Na6O23S6
CAS No. 129-46-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 50 mg/mL (34.99 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6997 mL 3.4986 mL 6.9972 mL 17.4929 mL
5 mM 0.1399 mL 0.6997 mL 1.3994 mL 3.4986 mL
10 mM 0.07 mL 0.3499 mL 0.6997 mL 1.7493 mL
20 mM 0.035 mL 0.1749 mL 0.3499 mL 0.8746 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Jindal HK, et al. Suramin affects DNA synthesis in HeLa cells by inhibition of DNA polymerases. Cancer Res. 1990 Dec 15;50(24):7754-7. 2. Nautiyal A, et al. Suramin is a potent and selective inhibitor of Mycobacterium tuberculosis RecA protein and the SOS response: RecA as a potential target for antibacterial drug discovery. J Antimicrob Chemother. 2014 Jul;69(7):1834-43. 3. Bojanowski K, et al. Suramin is an inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcomacells. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3025-9. 4. Izikki M, et al. The beneficial effect of suramin on monocrotaline-induced pulmonary hypertension in rats. PLoS One. 2013 Oct 15;8(10):e77073. 5. Wan Y, Feng B, You Y, et al. Microglial Displacement of GABAergic Synapses Is a Protective Event during Complex Febrile Seizures[J]. Cell Reports. 2020, 33(5): 108346.

文献引用

1. Wan Y, Feng B, You Y, et al. Microglial Displacement of GABAergic Synapses Is a Protective Event during Complex Febrile Seizures. Cell Reports. 2020, 33(5): 108346
SRT3657 UBCS039 SIRT5 inhibitor 5 SIRT-IN-1 SIRT5 inhibitor 9 Thiomyristoyl 5-Feruloylquinic acid MC3482

相关化合物库

该产品包含在如下化合物库中:
抗癌活性化合物库 抗癌药物库 抗癌临床化合物库 抗衰老化合物库 抗COVID-19化合物库 FDA上市及药典收录分子库 经典已知活性库 血管生成库 临床前化合物库 细胞凋亡化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
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% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Suramin Sodium Salt 129-46-4 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism Microbiology/Virology Phosphatase SARS-CoV Sirtuin Reverse Transcriptase Topoisomerase Parasite phosphatases DNA antiparasitic BAY 205 anti-angiogenic Inhibitor IP5K 苏拉明钠 Suramin hexasodium anti-neoplastic inhibit NF060 NF 060 BAY-205 protein-tyrosine PTPases Suramin hexasodium salt Suramin antitrypanosomal SARS coronavirus BAY205 苏拉明钠盐 NF-060 inhibitor

 

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