规格

价格

库存

数量

1 mg

¥ 239

现货

5 mg

¥ 548

现货

10 mg

¥ 805

现货

25 mg

¥ 1,430

现货

50 mg

¥ 2,380

现货

100 mg

¥ 3,350

现货

1 mL x 10 mM (in DMSO)

¥ 1,120

现货

生物活性

产品描述	Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.
靶点活性	SIRT5:22 μM, DNA topo II:5 μM, SIRT1:297 nM, SIRT2:1.15 μM
体外活性	Suramin 在培养的HeLa细胞中抑制细胞增殖和DNA合成。40 μM suramin 完全抑制了SV40 DNA的复制。与DNA聚合酶δ（IC50=36 μM）相比，DNA聚合酶α对较低浓度的suramin更敏感（IC50=8 μM），而DNA聚合酶β对该化合物相对不敏感（IC50=90 μM）[1]。Suramin是细菌RecA蛋白DNA链交换和ATP酶活性的强效抑制剂。Suramin抑制RecA催化的LexA抑制因子的蛋白水解切割。Suramin的抑制作用机制涉及其瓦解RecA-单链DNA丝的能力[2]。Suramin是核酶DNA拓扑异构酶II的强效抑制剂。Suramin抑制纯化的酵母拓扑异构酶II，其IC50约为5 μM[3]。
体内活性	与对照组大鼠相比，经Suramin处理后第21天的肺动脉压力、右心室肥大以及远端血管肌化指标均有所降低。Suramin的治疗能够抑制PA-SMC的增殖，并减轻炎症反应与胶原蛋白的沉积[4]。
激酶实验	The ATPase assay is performed in a 10 μL reaction mixture containing 20 mM Tris-HCl (pH 7.5), 1 mM DTT, 8 mM MgCl2, 5 μM M13 circular ssDNA, 2.5 μM RecA from the specified bacterial species and increasing concentrations of suramin. The reaction is initiated by the addition of 2 mM [α-32P]ATP, incubated for 30 min at 37°C and stopped by the addition of 25 mM EDTA[2].
别名	苏拉明钠盐, 苏拉明钠, Suramin hexasodium salt, NF-060, BAY-205

化学信息

分子量	1429.15
分子式	C₅₁H₃₄N₆Na₆O₂₃S₆
CAS No.	129-46-4
Smiles	[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Cc1ccc(cc1NC(=O)c1cccc(NC(=O)Nc2cccc(c2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(c3cc(cc(c23)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c1)C(=O)Nc1ccc(c2cc(cc(c12)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 252.5 mg/mL (176.68 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (1.4 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.6997 mL	3.4986 mL	6.9972 mL	34.9858 mL
5 mM	0.1399 mL	0.6997 mL	1.3994 mL	6.9972 mL
10 mM	0.0700 mL	0.3499 mL	0.6997 mL	3.4986 mL
20 mM	0.0350 mL	0.1749 mL	0.3499 mL	1.7493 mL
50 mM	0.0140 mL	0.0700 mL	0.1399 mL	0.6997 mL
100 mM	0.0070 mL	0.0350 mL	0.0700 mL	0.3499 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Suramin Sodium Salt

Suramin Sodium Salt

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

Suramin Sodium Salt

Suramin Sodium Salt