Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rebamipide (OPC12759) 是一种粘膜保护剂,可诱导COX-2表达,增加PGE2水平,并以 COX-2 依赖性方式增强胃粘膜防御。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 mg | ¥ 334 | 现货 | ||
1 g | ¥ 415 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 142 | 现货 |
产品描述 | Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense. |
别名 | Proamipide, OPC12759, 瑞巴派特 |
分子量 | 370.79 |
分子式 | C19H15ClN2O4 |
CAS No. | 90098-04-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 69 mg/mL (186.1 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6969 mL | 13.4847 mL | 26.9694 mL | 67.4236 mL |
5 mM | 0.5394 mL | 2.6969 mL | 5.3939 mL | 13.4847 mL | |
10 mM | 0.2697 mL | 1.3485 mL | 2.6969 mL | 6.7424 mL | |
20 mM | 0.1348 mL | 0.6742 mL | 1.3485 mL | 3.3712 mL | |
50 mM | 0.0539 mL | 0.2697 mL | 0.5394 mL | 1.3485 mL | |
100 mM | 0.027 mL | 0.1348 mL | 0.2697 mL | 0.6742 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Rebamipide 90098-04-7 GPCR/G Protein Immunology/Inflammation Neuroscience oxidation-reduction Free radical scavengers COX Prostaglandin Receptor AGS cells inhibit mucosal protection gastroduodenal ulcer Inhibitor OPC-12759 COX-2 gastric cancer Cyclooxygenase PGE2 Proamipide OPC12759 OPC 12759 gastritis 瑞巴派特 inhibitor