store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Novobiocin 是一种具有口服活性和有效性的的抗生素。Novobiocin 是 DNA 促旋酶抑制剂和热休克蛋白 90 (Hsp90) 拮抗剂,对促旋酶和Hsp90 具有抑制作用。 Novobiocin 具有抗正痘活性,可用于研究高度耐药性肺炎球菌感染。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 265 | 现货 | ||
5 mg | ¥ 580 | 现货 | ||
10 mg | ¥ 870 | 现货 | ||
25 mg | ¥ 1,570 | 现货 | ||
50 mg | ¥ 2,360 | 现货 | ||
100 mg | ¥ 3,540 | 现货 | ||
500 mg | ¥ 7,790 | 现货 |
产品描述 | Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on gyrase and Hsp90. Novobiocin has anti-positive activity and can be used to study highly resistant pneumococcal infections. |
体外活性 |
Novobiocin (1 mM) competitively hinders the binding of ATP to gyrase B, disrupting nucleotide binding, and impairs the interaction between the co-chaperones Hsc70 and p23 with Hsp90.[1] Novobiocin (200 µM; 24 h) results in the inhibition of the repair rate of DNA interstrand cross-links induced by both cisplatin (cis-DDP) and BCNU. This is accompanied by a corresponding reduction in the clonogenic survival of human glioblastoma multiforme cells.[2] Novobiocin (0.3 mM; 48 hours) triggers caspase-3/7 enzyme-dependent apoptosis assays, resulting in an approximate three- to fivefold increase in the number of apoptotic cells in K562, HL60, and Mutz-2.[5] |
体内活性 | Novobiocin (25, 50, 100, 200 mg/kg; s.c.; 4 times at 1, 5, 24, and 48 h after infection; Adult female Swiss mice (30g) with sepsis induced by the penicillin-susceptible strain (AR33118)) shows anti-infection activity in mice infected with amoxicillin-resistant Streptococcus pneumoniae.[3] |
别名 | U-6391, U 6391, U6391, Cathomycin, Albamycin |
分子量 | 612.62 |
分子式 | C31H36N2O11 |
CAS No. | 303-81-1 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Novobiocin 303-81-1 Apoptosis Cytoskeletal Signaling DNA Damage/DNA Repair Metabolism Microbiology/Virology Virus Protease HSP Antibacterial Antibiotic DNA gyrase U-6391 U 6391 U6391 Cathomycin Albamycin Inhibitor inhibitor inhibit