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Lipopolysaccharides

Lipopolysaccharides

产品编号 T11855   CAS T11855
别名: 脂多糖, LPS

Lipopolysaccharides (LPS) 是一种高免疫原性抗原,可以增强免疫反应。脂多糖是一种来源于革兰氏阴性菌外膜外叶的内毒素。脂多糖由抗原 O 特异性链、核心寡糖和脂质 A 组成。

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Lipopolysaccharides Chemical Structure
Lipopolysaccharides, CAS T11855
规格 价格/CNY 货期 数量
1 mg ¥ 449 现货
5 mg ¥ 987 现货
10 mg ¥ 1,760 现货
25 mg ¥ 3,170 现货
50 mg ¥ 4,760 现货
产品目录号及名称: Lipopolysaccharides (T11855)
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天然产物信息
生物活性
化学信息
存储 & 溶解度
参考文献
结构类型
产品描述 Lipopolysaccharide is a highly immunogenic antigen which can enhance immune responses.Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharide consists of an antigen O-specific chain, a core oligosaccharide and lipid A.
别名 脂多糖, LPS
分子量 4899.92
分子式 C205H366N3O117P5
CAS No. T11855

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: 5 mg/mL (Need ultrasonic)

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Rietschel ET, et al. Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J. 1994 Feb;8(2):217-25. 2. Kabanov DS, et al. Structural analysis of lipopolysaccharides from Gram-negative bacteria. Biochemistry (Mosc). 2010 Apr;75(4):383-404. 3. Heinrichs DE, et al. Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Mol Microbiol. 1998 Oct;30(2):221-32. 4. Kajiwara Y, et al. A critical role for human caspase-4 in endotoxin sensitivity. J Immunol. 2014 Jul 1;193(1):335-43. 5. Lai HT, et al. Effects of repeated intratracheally administered lipopolysaccharide on primary and secondary specific antibody responses and on body weight gain of broilers. Poult Sci. 2011 Feb;90(2):337-51.

文献引用

1. Wang Y, Luo W, Wang X, et al. MAMDC2, a gene highly expressed in microglia in experimental models of Alzheimers Disease, positively regulates the innate antiviral response during neurotropic virus infection. Journal of Infection. 2022, 84(2): 187-204 2. Chen J, Zhao L, Ding X, et al. Aβ1–40 Oligomers Trigger Neutrophil Extracellular Trap Formation through TLR4- and NADPH Oxidase-Dependent Pathways in Age-Related Macular Degeneration. Oxidative Medicine and Cellular Longevity. 2022 3. Gu X, Weng R, Hou J, et al. Endothelial miR-199a-3p regulating cell adhesion molecules by targeting mTOR signaling during inflammation. European Journal of Pharmacology. 2022: 174984 4. Zhang Z, Yuan Q, Hu X, et al. Rifaximin protects SH‐SY5Y neuronal cells from iron overload‐induced cytotoxicity via inhibiting STAT3/NF‐κB signaling. Cell Biology International.. 5. Wang Z, Sang M, Zhang Y, et al.BmKK2, a thermostable Kv1. 3 blocker from Buthus martensii Karsch (BmK) scorpion, inhibits the activation of macrophages via Kv1. 3-NF-κB-NLPR3 axis.Journal of Ethnopharmacology.2023: 116624. 6. Zhou Y, Zhou L, Jin W, et al.Chronic Allergen Exposure Contributes to Steroid Resistance via Increased Phosphorylation of Glucocorticoid Receptors S226 and p38 MAPK in a Mouse Model of Asthma.Iranian Journal of Allergy, Asthma and Immunology.2023: 1-10. 7. Zheng X, Zhang C, Li L, et al.Improvement of astrocytic gap junction involves the anti-depressive effect of celecoxib through inhibition of NF-κB.Brain Research Bulletin.2024: 110871.
View product citations for antibody PRODUCT_CODE on CiteAb

相关化合物库

该产品包含在如下化合物库中:
NO PAINS 化合物库 高通量筛选天然产物库 免疫/炎症分子化合物库 临床期小分子药物库 抗感染化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
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计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Lipopolysaccharides T11855 Others 脂多糖 LPS Inhibitor inhibitor inhibit

 

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