Lasalocid sodium

Name: Lasalocid sodium
Brand: TargetMol
SKU: T15716
Price: 218 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.58%

货号 T15716Cas号 25999-20-6

别名 拉沙洛西钠, 拉沙里菌素, Lasalocid-A sodium, Ionophore X-537A sodium, Antibiotic X-537A sodium

Lasalocid sodium (Lasalocid-A sodium) 是一种抗菌剂。

Lasalocid sodium

一键复制产品信息

很棒

纯度: 99.58%

货号 T15716 别名 拉沙洛西钠, 拉沙里菌素, Lasalocid-A sodium, Ionophore X-537A sodium, Antibiotic X-537A sodiumCas号 25999-20-6

Lasalocid sodium (Lasalocid-A sodium) 是一种抗菌剂。

规格	价格	库存
1 mg	¥ 218	现货
5 mg	¥ 496	现货
10 mg	¥ 828	现货
25 mg	¥ 1,490	现货
50 mg	¥ 2,230	现货
100 mg	¥ 3,160	现货
500 mg	¥ 6,870	现货
1 mL x 10 mM (in DMSO)	¥ 672	现货

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COA HNMR LCMS 产品操作手册

产品介绍

Lasalocid sodium AI Summary

Lasalocid sodium exhibits a broad spectrum of bioactivities. It demonstrates anti-viral activity against the West Nile Virus with an IC50 of 8300.0 nM and inhibits multiple targets such as ROR gamma, lipid storage modulators, NS1 protein of Influenza, DNA Polymerase Beta, Nrf2 pathway, and BAZ2B, with potencies varying from 1636.0 nM to 79432.8 nM. This compound also shows cytotoxicity against various human tumor cell lines (GI50: 348.34 nM to 6471.43 nM) and HepG2 cells with an IC50 > 100,000.0 nM. Moreover, it effectively inhibits liver stage Plasmodium berghei infection in HepG2 cells (IC50: 11.0 nM). Additionally, Lasalocid sodium inhibits horse butyrylcholinesterase (10.53% inhibition at 2 mg/ml) and slightly decreases activity against electric eel acetylcholinesterase (-1.88% at the same concentration). It impacts sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells, showing IC50 values of 776.25 nM and 478.63 nM respectively, and enhances human PXR activity, inducing CYP3A4 enzyme with an efficacy of 140.7% and an EC50 of 5600.0 nM in a TR-FRET assay. The compound also has a competitive binding efficacy of 93.6% relative to SR12813 for human PXR LBD..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Lasalocid sodium (Lasalocid-A sodium) is a cationic ionophore antibiotic obtained from Streptomyces lasaliensis that, among other effects, dissociates the calcium fluxes in muscle fibers. Lasalocid sodium is used as a coccidiostat, especially in poultry.
别名	拉沙洛西钠, 拉沙里菌素, Lasalocid-A sodium, Ionophore X-537A sodium, Antibiotic X-537A sodium

化学信息

分子量	612.77
分子式	C₃₄H₅₃NaO₈
CAS No.	25999-20-6
Smiles	[Na+].CC[C@H]([C@H]1O[C@@](CC)(C[C@@H]1C)[C@H]1CC[C@](O)(CC)[C@H](C)O1)C(=O)[C@@H](C)[C@@H](O)[C@H](C)CCc1ccc(C)c(O)c1C([O-])=O
密度	1.119g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: < 0.1 mg/mL (insoluble)

DMSO: 100 mg/mL (163.19 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.53 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6319 mL	8.1597 mL	16.3193 mL	81.5967 mL
5 mM	0.3264 mL	1.6319 mL	3.2639 mL	16.3193 mL
10 mM	0.1632 mL	0.8160 mL	1.6319 mL	8.1597 mL
20 mM	0.0816 mL	0.4080 mL	0.8160 mL	4.0798 mL
50 mM	0.0326 mL	0.1632 mL	0.3264 mL	1.6319 mL
100 mM	0.0163 mL	0.0816 mL	0.1632 mL	0.8160 mL