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Isavuconazole

Isavuconazole

产品编号 T2305   CAS 241479-67-4
别名: 艾沙康唑, BAL-4815, RO-0094815

Isavuconazole (RO-0094815) 是一种三唑类前药,对酵母、霉菌和二型真菌具有抗真菌活性。它抑制麦角固醇生物合成,导致真菌膜结构和功能的破坏。它是 CYP3A4抑制剂。

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Isavuconazole Chemical Structure
Isavuconazole, CAS 241479-67-4
规格 价格/CNY 货期 数量
1 mg ¥ 263 现货
2 mg ¥ 369 现货
5 mg ¥ 647 现货
10 mg ¥ 977 现货
25 mg ¥ 1,660 现货
50 mg ¥ 2,480 现货
100 mg ¥ 3,690 现货
200 mg ¥ 5,260 现货
500 mg ¥ 7,930 现货
1 mL * 10 mM (in DMSO) ¥ 665 现货
其他形式的 Isavuconazole:
千万补贴 助力科研
BCA蛋白浓度测定试剂盒限时半价
Venetoclax限时半价
产品目录号及名称: Isavuconazole (T2305)
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选择批次  
纯度: 100%
纯度: 99.97%
纯度: 99.97%
纯度: 98%
更多批次查询请联系客服
生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Isavuconazole (RO-0094815)(BAL-4815; RO-0094815) is the active component of the new azole antifungal agent BAL8557 with MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabrata.
激酶实验 SP2509 activity assays: Test compounds are diluted to 20 × the desired test concentration in 100% DMSO and 2.5?μL of the diluted drug sampleis added to a black 384-well plate. The LSD1 enzyme stock is diluted 17-fold with assay buffer and 40?μL of the diluted LSD1 enzyme is added to the appropriate wells. Substrate, consisting of horseradish peroxidase, dimethyl K4 peptide corresponding to the first 21 amino acids of the N-terminal tail of histone H3, and 10-acetyl-3,7-dihydroxyphenoxazine is then added to wells. Resorufin is analyzed on an Envision plate reader with an excitation wavelength of 530?nm and an emission wavelength of 595?nm. The activity of SP2509 on the other oxidases is determined by using commercially available kits. The glucose oxidase activity (which also noncovalently binds FAD in an elongate conformation), is determined using the glucose oxidase kit. The MAO assays are performed using the MAO-glo kit with MAO-A and MAO-B.
别名 艾沙康唑, BAL-4815, RO-0094815
分子量 437.47
分子式 C22H17F2N5OS
CAS No. 241479-67-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 70 mg/mL (160.01 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2859 mL 11.4294 mL 22.8587 mL 57.1468 mL
5 mM 0.4572 mL 2.2859 mL 4.5717 mL 11.4294 mL
10 mM 0.2286 mL 1.1429 mL 2.2859 mL 5.7147 mL
20 mM 0.1143 mL 0.5715 mL 1.1429 mL 2.8573 mL
50 mM 0.0457 mL 0.2286 mL 0.4572 mL 1.1429 mL
100 mM 0.0229 mL 0.1143 mL 0.2286 mL 0.5715 mL

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TargetMol Library Books参考文献

1. Seifert H, et al. Antimicrob Agents ChemOthers. 2007 May;51(5):1818-21. 2. Lau S K P, Xing F, Tsang C C, et al. Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China[J]. Mycoses. 2019 May;62(5):450-457. 3. Tsang C C, Tang J Y M, Ye H, et al. Rare/cryptic Aspergillus species infections and importance of antifungal susceptibility testing[J]. Mycoses. 2020, 63(12): 1283-1298. 4. Tsang C C, Chan K F, Chan W, et al. Hepatic phaeohyphomycosis due to a novel dematiaceous fungus, Pleurostoma hongkongense sp. nov., and importance of antifungal susceptibility testing[J]. Emerging Microbes & Infections. 2020: 1-53. 5. Tsang C C, Tang J Y M, Chan K F, et al. Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing[J]. Emerging microbes & infections. 2019;8(1):531-541.

TargetMol Library Books文献引用

1. Ma L, Lian Y, Tang J, et al. Identification of the Anti-Fungal Drug Fenticonazole Nitrate as a Novel PPARγ-Modulating Ligand With Good Therapeutic Index: Structure-Based Screening and Biological Validation. Pharmacological Research. 2021: 105860. 2. Quan C, Chen Y, Wang X, et al. Loss of histone lysine methyltransferase EZH2 confers resistance to tyrosine kinase inhibitors in non-small cell lung cancer. Cancer Letters. 2020 3. Tsang C C, Tang J Y M, Chan K F, et al. Diversity of phenotypically non-dermatophyte, non-Aspergillus filamentous fungi causing nail infections: importance of accurate identification and antifungal susceptibility testing. Emerging Microbes & Infections. 2019, 8(1): 531-541 4. Tsang C C, Chan K F, Chan W, et al. Hepatic phaeohyphomycosis due to a novel dematiaceous fungus, Pleurostoma hongkongense sp. nov., and importance of antifungal susceptibility testing. Emerging Microbes & Infections. 2021 Dec;10(1):81-96. 5. Lau S K P, Xing F, Tsang C C, et al. Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China. Mycoses. 2019, 62(5): 450-457
BI 653048 phosphate Verapamil hydrochloride Stiripentol TAK-700 7-BFC Clobetasol propionate Quinidine sulfate dihydrate Nampt-IN-5

相关化合物库

该产品包含在如下化合物库中:
抗癌药物库 药物功能重定位化合物库 抑制剂库 EMA 上市药物库 抗癌临床化合物库 抗癌上市药物库 NO PAINS 化合物库 经典已知活性库 FDA上市及药典收录分子库 免疫/炎症分子化合物库

TargetMol Calculator剂量换算

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请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

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您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Isavuconazole 241479-67-4 Metabolism Microbiology/Virology P450 Antibiotic Antifungal 艾沙康唑 prodrug dimorphic Inhibitor ergosterol CYPs RO 0094815 triazole BAL4815 biosynthesis Fungal fungi RO0094815 yeasts BAL-4815 inhibit BAL 4815 Cytochrome P450 RO-0094815 molds inhibitor

 

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