Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AM103 是一种有效的特异性 FLAP 抑制剂 (IC50 = 4.2 nM)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,830 | 现货 | ||
2 mg | ¥ 2,720 | 现货 | ||
5 mg | ¥ 4,430 | 现货 | ||
10 mg | ¥ 6,330 | 现货 | ||
25 mg | ¥ 9,550 | 现货 | ||
50 mg | ¥ 12,800 | 现货 | ||
100 mg | ¥ 17,380 | 现货 |
产品描述 | AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM). |
靶点活性 | FLAP:4.2 nM |
体外活性 | AM103 is against the 5 most common CYP isoforms with IC50s >30 μM for CYP2D6 and >50 μM for CYP3A4, CYP2C9, CYP2C19, and CYP1A2[1]. AM103 shows IC50s of 350, 113, and 117 nM against human, rat, and mouse whole-blood ionophore-stimulated LTB4 production, respectively[2]. |
体内活性 | AM103 has high bioavailability of 64%, low clearance of 2.9 mL/min/kg, low volume of distribution of 0.41 L/kg, and a long i.v. half-life of 5.2 h in dogs. AM103 (10 mg/kg) inhibits the increase in CysLTs and EPO by approximately 60% and reduces the level of IL-5[1]. In a model of chronic lung inflammation using ovalbumin-primed and challenged BALB/c mice, AM103 reduces eosinophil peroxidase, CysLTs, and IL-5 in the bronchoalveolar lavage fluid. AM103 increases survival time in mice exposed to a lethal intravenous injection of platelet-activating factor. In the rat lung challenged in vivo with calcium ionophore, AM103 inhibits LTB4 and cysteinyl leukotriene production with ED50 values of 0.8 and 1 mg/kg, respectively[2]. |
别名 | AM 103 |
分子量 | 631.76 |
分子式 | C36H38N3NaO4S |
CAS No. | 1147872-22-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 180 mg/mL (284 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.5829 mL | 7.9144 mL | 15.8288 mL | 39.572 mL |
5 mM | 0.3166 mL | 1.5829 mL | 3.1658 mL | 7.9144 mL | |
10 mM | 0.1583 mL | 0.7914 mL | 1.5829 mL | 3.9572 mL | |
20 mM | 0.0791 mL | 0.3957 mL | 0.7914 mL | 1.9786 mL | |
50 mM | 0.0317 mL | 0.1583 mL | 0.3166 mL | 0.7914 mL | |
100 mM | 0.0158 mL | 0.0791 mL | 0.1583 mL | 0.3957 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
AM103 1147872-22-7 Immunology/Inflammation FLAP AM-103 AM 103 Inhibitor inhibitor inhibit