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MAPK

MAPK

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis.
TargetMol
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Cat. No. Product Name CAS No. Purity Chemical Structure
TN1660 Ganoderic acid C1
灵芝酸C1
95311-97-0
TargetMol Chemical Structure Ganoderic acid C1
Ganoderic acid C1 是分离自 G. lucidum 中的天然产物,能够抑制小鼠巨噬细胞TNF-α 的生成。
TN1338 7Beta-Hydroxycholesterol
胆甾-5-烯-3,7二醇
566-27-8 98%
TargetMol Chemical Structure 7Beta-Hydroxycholesterol
7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells...
TN2694 2,3-Dihydro-3-methoxywithaferin A
化合物 TN2694
21902-96-5 98%
TargetMol Chemical Structure 2,3-Dihydro-3-methoxywithaferin A
2,3-Dihydro-3-methoxywithaferin A is a natural withanolide , is cytotoxic to human cancer cells, and is a candidate anticancer natural compound. It protects norm...
TN2123 Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside
槲皮素3-O-(6''-没食子酰基)-Β-D-半乳糖苷
53171-28-1 98%
TargetMol Chemical Structure Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside
Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside can effectively induce apoptosis via p53, MAPKs and the mitochondrial apoptotic pathways.
TN1269 3β-Methoxy-2,3-dihydrowithaferin A
化合物3beta-Methoxy-2,3-dihydrowithaferin A
73365-94-3 98%
TargetMol Chemical Structure 3β-Methoxy-2,3-dihydrowithaferin A
3beta-Methoxy-2,3-dihydrowithaferin A has cytoprotective activity, it protects normal cells against stress.
TN4038 Eupatolide
泽兰内酯
6750-25-0 98%
TargetMol Chemical Structure Eupatolide
Eupatolide 是从 Inula japonica 的花中分离出来的,具有抗炎活性。 Eupatolide 可用于研究乳腺癌细胞对 TRAIL 的耐药性。
TN3587 Capillarisin
化合物 TN3587
56365-38-9 98%
TargetMol Chemical Structure Capillarisin
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN2844 (2R,3S)-Dihydrodehydroconiferyl alcohol
化合物 TN2844
126253-41-6 98%
TargetMol Chemical Structure (2R,3S)-Dihydrodehydroconiferyl alcohol
(2R,3S)-Dihydrodehydroconiferyl alcohol can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such...
TN1806 Isotetrandrine
异汉防己甲素
477-57-6 98%
TargetMol Chemical Structure Isotetrandrine
Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of...
TN4877 Quercetin 3,4'-dimethyl ether
化合物 TN4877
33429-83-3 98%
TargetMol Chemical Structure Quercetin 3,4'-dimethyl ether
Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ...
TN1645 Flavokawain C
2',4-二羟基-4',6'-二甲氧基查耳酮
56798-34-6 98%
TargetMol Chemical Structure Flavokawain C
Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle...
TN3691 Communic acid
化合物 TN3691
2761-77-5 98%
TargetMol Chemical Structure Communic acid
Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic...
TN2511 Britannilactone diacetate
化合物 TN2511
1286694-67-4 98%
TargetMol Chemical Structure Britannilactone diacetate
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
TN3805 Dehydrogeijerin
化合物 TN3805
16850-91-2 98%
TargetMol Chemical Structure Dehydrogeijerin
Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that it could be a potential candidate for the treatment of...
TN2328 Zeylenone
山椒子烯酮
193410-84-3 98%
TargetMol Chemical Structure Zeylenone
Zeylenone 是一种来自 Uvaria grandiflora的环己烯氧化物,具有抗肿瘤和抗癌细胞增殖活性,通过 PI3K/AKT/mTOR 和 MAPK/ERK 信号通路抑制宫颈癌细胞增殖,诱导细胞凋亡 (apoptosis)。
T72956 Darizmetinib
化合物 Darizmetinib
2369583-33-3 98%
TargetMol Chemical Structure Darizmetinib
Darizmetinib (HRX-0215) 是一种MKK4抑制剂,MKK4 的抑制导致 MKK7 和 JNK1 信号通路的增强,进而激活转录因子 ATF2 和 ELK1,促进细胞增殖和肝再生。
TN4094 Gallocatechin gallate
化合物 TN4094
5127-64-0 98%
TargetMol Chemical Structure Gallocatechin gallate
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
TN5100 Taspine
化合物 TN5100
602-07-3 98%
TargetMol Chemical Structure Taspine
Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
TN3397 Alpinumisoflavone
化合物 TN3397
34086-50-5 98%
TargetMol Chemical Structure Alpinumisoflavone
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
TN4489 Manassantin A
化合物 TN4489
88497-87-4 98%
TargetMol Chemical Structure Manassantin A
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
Ganoderic acid C1
TN1660
Ganoderic acid C1 是分离自 G. lucidum 中的天然产物,能够抑制小鼠巨噬细胞TNF-α 的生成。
7Beta-Hydroxycholesterol
TN1338
7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells...
2,3-Dihydro-3-methoxywithaferin A
TN2694
2,3-Dihydro-3-methoxywithaferin A is a natural withanolide , is cytotoxic to human cancer cells, and is a candidate anticancer natural compound. It protects norm...
Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside
TN2123
Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside can effectively induce apoptosis via p53, MAPKs and the mitochondrial apoptotic pathways.
3β-Methoxy-2,3-dihydrowithaferin A
TN1269
3beta-Methoxy-2,3-dihydrowithaferin A has cytoprotective activity, it protects normal cells against stress.
Eupatolide
TN4038
Eupatolide 是从 Inula japonica 的花中分离出来的,具有抗炎活性。 Eupatolide 可用于研究乳腺癌细胞对 TRAIL 的耐药性。
Capillarisin
TN3587
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
(2R,3S)-Dihydrodehydroconiferyl alcohol
TN2844
(2R,3S)-Dihydrodehydroconiferyl alcohol can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such...
Isotetrandrine
TN1806
Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of...
Quercetin 3,4'-dimethyl ether
TN4877
Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ...
Flavokawain C
TN1645
Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle...
Communic acid
TN3691
Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic...
Britannilactone diacetate
TN2511
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
Dehydrogeijerin
TN3805
Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that it could be a potential candidate for the treatment of...
Zeylenone
TN2328
Zeylenone 是一种来自 Uvaria grandiflora的环己烯氧化物,具有抗肿瘤和抗癌细胞增殖活性,通过 PI3K/AKT/mTOR 和 MAPK/ERK 信号通路抑制宫颈癌细胞增殖,诱导细胞凋亡 (apoptosis)。
Darizmetinib
T72956
Darizmetinib (HRX-0215) 是一种MKK4抑制剂,MKK4 的抑制导致 MKK7 和 JNK1 信号通路的增强,进而激活转录因子 ATF2 和 ELK1,促进细胞增殖和肝再生。
Gallocatechin gallate
TN4094
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
Taspine
TN5100
Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
Alpinumisoflavone
TN3397
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
Manassantin A
TN4489
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
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