vitamin b-3

Niacin (Nicotinic acid)，也称为烟酸和维生素 B3，是一种水溶性必需的 B 族维生素，用于治疗维生素缺乏症以及高脂血症，血脂异常，高甘油三酯血症，并降低心肌梗塞的风险

Nicotinamide是一种维生素B3的衍生物，是 SIRT1 (IC50=50-180 μM) 和 SIRT2 (IC50=2 μM) 的抑制剂。Nicotinamide 可作为烟酰胺腺嘌呤二核苷酸或 NAD+ 的前体，可通过膳食摄入来补充，能预防或治疗黑舌病和糙皮病。

Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM). Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosylceramide, sphingomyelin, free fatty acids, and cholesterol in primary human keratinocytes. Nicotinamide (40 µM) induces apoptosis in SNU-398, SNU-739, and HepG2 hepatocellular carcinoma (HCC) cells, and it prevents the formation of neoplastic lesions in a diethylnitrosamine-induced mouse model of HCC. Unlike niacin, nicotinamide does not reduce plasma lipid levels or induce flushing.

Vitamin B3-d4 (Nicotinic acid-(ring-d4)) 是 Niacin 的氘代物，可用于跟踪 Niacin 在体内的代谢。

Biotin (Vitamin B7) sodium 是一种水溶性维生素 B，是人体五种羧化酶的辅酶，参与脂肪酸、异亮氨酸和缬氨酸的合成，并参与糖异生。Biotin sodium 是细胞生长、脂肪酸产生以及脂肪和氨基酸代谢的必需物质。

Methyl 3-(2,4-dihydroxyphenyl)propionate是一种新型的维生素E衍生物，能够抑制酪氨酸酶（tyrosinase），从而能够抗氧化和抑制对紫外线B （UVB）诱导的色素沉着，具有潜在的美白作用。