trap6

TRAP-6 (Thrombin Receptor Activator Peptide 6) 是一种多肽片段，是选择性的蛋白酶激活受体 1 (PAR1) 激动剂，通过凝血酶受体激活人血小板。

FLLRN是一种具有生物活性的(PAR1特异性拮抗肽)。

TRAP-6 peptide is a hexapeptide corresponding to residues 42-47 of protease-activated receptor 1 (PAR1). It acts as an agonist of PAR1, inducing platelet aggregation in human platelet-rich plasma ex vivo (EC50 = 0.8 μM). TRAP-6 (0.3 and 0.6 mg kg) has a triphasic effect on mean arterial blood pressure (MAP) in anesthetized rats with a short decrease, an increase, and then a longer decrease in MAP following intravenous administration.

TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide.

TRAP-6 amide acetate 是一种 PAR-1 凝血酶受体激动剂肽。

TRAP-6 amide TFA is a PAR-1 thrombin receptor agonist peptide.

TRAP-6-IN-1 (Compound 8) 是胶原蛋白和TRAP-6的双重抑制剂，IC50值分别为 17.12 μM 和 11.88 μM。TRAP-6-IN-1 非竞争性抑制激动剂诱导的血小板聚集。

iso-TRAP-6(iso-SFLLRN)是一个由异丝氨酸代替丝氨酸后的六肽，是一种蛋白酶激活受体 1 (PAR1) 激动剂，可通过 PAR-1 激活血小板。iso-TRAP-6 抵抗血浆氨基肽酶降解的能力比TRAP-6 强。