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TargetMol产品目录中 "

tnf‐α‐converting enzyme

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  • 抑制剂&激动剂
    5
    TargetMol | Inhibitors_Agonists
  • KP-457
    KP 457, KP457
    T777781365803-52-6
    KP-457是一种特异性解聚素-金属蛋白酶 17 (ADAM17) 抑制剂,也是 TNFα 转化酶 TACE 抑制剂,可阻止可溶性 TNF (sTNF) 的产生。
    • ¥ 748
    In stock
    规格
    数量
  • Apratastat
    T14312287405-51-0
    Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) and it also can potently inhibit the release of TNF-α in vitro, ex vivo, and in vivo with IC50s of 144 ng mL in vitro and 81.7 ng mL ex vivo, respectively[1].
    • 待估
    35日内发货
    规格
    数量
  • mmp-9 inhibitor i
    T37726206549-55-5
    MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNFconverting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM). MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 μM.
    • 待估
    35日内发货
    规格
    数量
  • BMS-566394
    T69181503166-51-6
    BMS-566394 is a potent, exceptionally selective inhibitor of TNFconverting enzyme (TACE).
    • ¥ 11700
    6-8周
    规格
    数量
  • Zofenoprilat
    Zofenopril-SH,SQ 26,333
    T8376875176-37-3
    Zofenoprilat是一种血管紧张素转换酶(ACE; IC50 = 8 nM for the rabbit lung enzyme)的抑制剂,同时也是前体药zofenopril的活性代谢产物。它能够抑制分离的豚鼠小肠中由血管紧张素I或缓激肽诱导的收缩(EC50s = 3 and 1 nM, respectively)。在人类脐静脉内皮细胞(HUVECs)中,Zofenoprilat (10 nM)降低基础内皮素-1分泌和一氧化氮(NO)生成,并阻止TNF-α诱导的活性氧种(ROS)增加以及谷胱甘肽(GSH)水平降低。Zofenoprilat (10 µM)保护初级人类心脏微血管内皮细胞免受多柔比星诱导的细胞毒性。此外,Zofenoprilat (10 µM)还能增加HUVECs中的硫化氢(H2S)生成,以及细胞的黏着、迁移和增殖。在以400 µM浓度使用时,它可以减少Langendorff分离的大鼠心脏灌流缺血再灌注损伤模型中的舒张末压和乳酸脱氢酶(LDH)释放。
    • ¥ 1830
    35日内发货
    规格
    数量