tco-peg4-amine

TCO-PEG4-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Tetrazine-PEG4-amine (hydrochloride) 是用于合成抗体偶联活性分子 (ADC) 的可降解 (cleavable) ADC linker，其结构中包含四个PEG单元。该化合物亦为一种点击化学试剂，具有 Tetrazine 基团，能够与含 TCO 基团的分子通过逆电子需求 Diels-Alder 反应 (iEDDA) 进行高效反应。