tariquidar

Tariquidar (XR9576) 是一种特异性有效的P-糖蛋白抑制剂，Kd 为 5.1 nM。

Tariquidar dihydrochloride (XR9576 dihydrochloride) 是一种有效的特异性 P-glycoprotein(P-gp) 抑制剂，Kd 为 5.1 nM。

Tariquidar is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrug resistance in cancer. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drugs.

Tariquidar methanesulfonate hydrate (XR9576 methanesulfonate hydrate) 是一种具有选择性和高效性的 P-糖蛋白药物外排泵抑制剂，具有潜在的抗癌活性，诱导大鼠血脑屏障 P-糖蛋白抑制。

Jatrophane 5 demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).

2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-feeding insect, the cotton bollworm (Helicoverpa armigera). Jatrophane 2 also demonstrates the mo