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27

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6991	Nitroprusside disodium dihydrate 硝普钠二水合物,硝普钠,Sodium Nitroferricyanide(III) Dihydrate,Sodium Nitroprusside Dihydrate	Guanylate cyclase; Autophagy	Autophagy; GPCR/G Protein
	Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) 是一种血管扩张剂，通过在血液中自发释放 NO 发挥作用。它可在谷胱甘肽耗竭的成骨细胞中诱导自噬，用于急性高血压和心力衰竭的研究。
T1478	Ondansetron hydrochloride dihydrate 盐酸昂丹司琼,SN 307,NSC 665799,GR 38032,Ondansetron hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	Ondansetron hydrochloride dihydrate (GR 38032) 是5- HT3受体拮抗剂，可治疗化疗后的恶心和呕吐，有抗焦虑和抗精神病作用。
T0156	Rocuronium bromide ORG 9426,罗库溴铵,ORG 9426 (Bromide)	AChR	Neuroscience
	Rocuronium bromide (ORG 9426) 是一种氨基甾体类的、非去极化的神经肌肉受体抑制剂，也是一种肌肉松弛剂。
T27509	GW-493838 GW 493838X,GW 493838,GW493838,GW493838X,GW-493838X	Adenosine Receptor	GPCR/G Protein; Neuroscience
	GW-493838是一种有效的腺苷 A1A 受体激动剂，用于治疗血脂异常和神经性疼痛，对创伤或手术引起的疱疹后神经痛或周围神经损伤具有镇痛效果。
T0312	Toluidine Blue 氯托洛宁,Blutene chloride	Others	Others
	Toluidine Blue (Blutene chloride) 是碱性噻嗪异染染料，能够高度亲和酸性组织成分，广泛应用于活体组织的重要染色及特殊染色。
T38681	P-SCN-Bn-DOTA	Others	Others
	p-SCN-Bn-DOTA 是一种螯合剂，可同时螯合放射性核素和连接单克隆抗体，可作为放射引导手术的示踪剂，可用于肿瘤的放射免疫研究。
TQ0223	Lusutrombopag 芦曲泊帕,鲁索曲波帕,S-888711,Mulpleta	Thrombin; Thrombopoietin Receptor	Immunology/Inflammation; Proteases/Proteasome
	Lusutrombopag (Mulpleta) 是一种口服生物可利用的小分子血小板生成素 (TPO) 受体激动剂，用于选择性侵入性手术前患有血小板减少症的慢性肝病的患者。
T3316	Fluorometholone 氟米龙,Fluoromethalone,Cortilet,Oxylone,Delmeson	Glucocorticoid Receptor	Endocrinology/Hormones
	Fluorometholone (Fluoromethalone) 是合成糖皮质激素，具有抗炎和抗过敏作用。它可用作糖皮质激素受体激动剂，能够用于干眼症的研究。
T76828	Sonepcizumab LT 1009	LPL Receptor	GPCR/G Protein
	Sonepcizumab (LT 1009) 是一种完全人源化的抗 S1P 单克隆抗体。Sonepcizumab 具有抗癌活性，可用于研究转移性肾细胞癌 (mRCC) ，可预防青光眼滤过手术后的眼部瘢痕形成。
T3126	Bethanechol chloride (±)-Bethanechol,Urecholine,Myocholine,氯贝胆碱,Carbamyl-β-methylcholine chloride	AChR	Neuroscience
	Bethanechol chloride (Carbamyl-β-methylcholine chloride) 是一种拟副交感神经剂，是毒蕈碱型受体 (mAChR) 激动剂，通过直接刺激副交感神经系统的 mAChR 发挥作用。
T20187	Alizarin Cyanine Green F NSC41838,NSC-41838,酸性绿 25,NSC 41838	Others	Others
	Alizarin Cyanine Green F (NSC-41838) 是一种绿色染料。它用于为普通外科手术中使用的尼龙 66 和尼龙 6 不可吸收的手术缝合线着色，并用于一般药物的着色，包括用于眼部区域的药物。它也被提议用于半永久性染发剂配方中，作为化妆品成品中最大浓度为 0.3% 的直接染料。
T22232	Alfuzosin
	Alfuzosin 是选择性和竞争性的α1肾上腺素受体拮抗剂，可用于良性前列腺增生（BPH）的研究。
T25637	Laudexium methylsulfate Laudexium,Laudolissin methosulphate
	Laudexium methylsulfate is a neuromuscular blocking drug or skeletal muscle relaxant. It is used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
T34279	Refortan
	Refortan, as hydroxyethyl starch, can be used in surgery for maintaining hemostasis in patients.
T67614	Tranexamic Acid (Random Configuration)
	Tranexamic acid is a medication used to treat or prevent excessive blood loss from major trauma, surgery, tooth removal, nose bleeds, and heavy menstruation.
T32066	Hexafluronium Bromide Mylaxen,Hexafluorenium bromide,Milaxen,Hexafluorenium dibromide,Esafluronio bromuro
	Hexafluronium bromide is a neuromuscular blocker and nicotinic acetylcholine receptor antagonist used in anesthesiology to prolong and enhance the skeletal muscle relaxation of succinylcholine during surgery.
T71601	CU-2010
	CU-2010 is a synthetic serine protease inhibitor with antifibrinolytic and anticoagulant properties. CU-2010 dose-dependently reduces postoperative blood loss and improves postischemic recovery after cardiac surgery in a canine model.
T69232	Atropine Oxide Hydrochloride
	Atropine Oxide is a derivative of Atropine. Atropine is a medication to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate and to decrease saliva production during surgery. Atropine is a competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4 and M5. It is classified as an anticholinergic drug (parasympatholytic).
T37598	D-Glucosamine-6-sulfate
	D-Glucosamine-6-sulfate is a naturally occurring glycosaminoglycan. It activates the glmS ribozyme from B. subtilis, a Gram-positive bacterium, when used at a concentration of 200 μM. It has been used to form polyvalent dendrimer conjugates that inhibit angiogenesis and endothelial cell proliferation induced by FGF-2 in vitro and prevent scar tissue formation in a rabbit model of glaucoma surgery.
T71532	Fondaparinux free base
	Fondaparinux Free Base is a synthetic pentasaccharide that mediates the interaction of HEPARIN with ANTITHROMBINS and inhibits FACTOR Xa; it is used for prevention of VENOUS THROMBOEMBOLISM after surgery. Fondaparinux is a clinically approved anticoagulant pentasaccharide for the treatment of thrombotic diseases, displays better efficacy and biosafety than other heparin-based anticoagulant drugs.
T33638	Neostigmine Iodide SB 24,SB24,TL1321,TL 1321,TL-1321,SB-24
	Neostigmine Iodide is a parasympathic compound used as a reversible acetylcholinesterase inhibitor to improve muscle tone in patients with myasthenia gravis and in routine anesthesia to reverse the effects of non-depolarizing muscle relaxants such as rocu
T81266	Rizedisben GE3126
	Rizedisben(GE3126)为一荧光基团，应用于荧光成像引导之手术。其特性降低非特异性脂肪组织之荧光强度，并提升神经组织的可见性。
T25636	Laudexium Laudexium ion,Laudexium cation
	Laudexium is a neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs. It is used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle re
T75324	Azidocillin
	Azidocillin 是一种半合成青霉素，是一种具有口服活性的 β-内酰胺类抗生素 (antibiotic)。Azidocillin 具有叠氮化功能，并在细菌内 (bacteria) 保持靶向活性。Azidocillin 可用于研究牙科手术引起的骨炎，或中耳炎、肠球菌败血症和其他细菌感染性疾病。
T35461	δ14-Triamcinolone acetonide
	δ14-Triamcinolone acetonide is a potential impurity found in commercial preparations of triamcinolone acetonide. Triamcinolone acetonide is a synthetic corticosteroid. It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 μl of a ...
T22551	ACSF	Others	Others
	ACSF is often used as a replacement of CSF for perfusion of brain slices to preserve interneurons. ACSF is invented to reduce the incidence of cerebral edema and further suppress brain cell disorders. And ACSF is often used as an irrigation fluid or perfu
T35961	Prostaglandin Bx
	PGBx is a mixture of oligomers of PGB1 with a molecular weight of 1,000-1,500. It has antioxidant and free radical trapping activity that was first studied in isolated mitochondria.1 PGBx has anti-inflammatory and cytoprotective activity which may be attributed to inhibition of the 14 kDa sPLA2.2,3 At a dose of 1 mg/kg, PGBx significantly reduces the incidence of ulcers in rats.2References1. Polis, B.D., Polis, E., and Kwong, S. Protection and reactivation of oxidative phosphorylation in mitocho...

化合物

Nitroprusside disodium dihydrate

Cat.No: T6991

Synonym: 硝普钠二水合物,硝普钠,Sodium Nitroferricyanide(III) Dihydrate,Sodium Nitroprusside Dihydrate

Target: Guanylate cyclase, Autophagy

Ondansetron hydrochloride dihydrate

Cat.No: T1478

Synonym: 盐酸昂丹司琼,SN 307,NSC 665799,GR 38032,Ondansetron hydrochloride

Target: 5-HT Receptor

Rocuronium bromide

Cat.No: T0156

Synonym: ORG 9426,罗库溴铵,ORG 9426 (Bromide)

Target: AChR

Cat.No: T27509

Synonym: GW 493838X,GW 493838,GW493838,GW493838X,GW-493838X

Target: Adenosine Receptor

Cat.No: T0312

Synonym: 氯托洛宁,Blutene chloride

Target: Others

Cat.No: T38681

Target: Others

Cat.No: TQ0223

Synonym: 芦曲泊帕,鲁索曲波帕,S-888711,Mulpleta

Target: Thrombin, Thrombopoietin Receptor

Fluorometholone

Cat.No: T3316

Synonym: 氟米龙,Fluoromethalone,Cortilet,Oxylone,Delmeson

Target: Glucocorticoid Receptor

Cat.No: T76828

Synonym: LT 1009

Target: LPL Receptor

Bethanechol chloride

Cat.No: T3126

Synonym: (±)-Bethanechol,Urecholine,Myocholine,氯贝胆碱,Carbamyl-β-methylcholine chloride

Target: AChR

Alizarin Cyanine Green F

Cat.No: T20187

Synonym: NSC41838,NSC-41838,酸性绿 25,NSC 41838

Target: Others

Cat.No: T22232

Laudexium methylsulfate

Cat.No: T25637

Synonym: Laudexium,Laudolissin methosulphate

Cat.No: T34279

Tranexamic Acid (Random Configuration)

Cat.No: T67614

Hexafluronium Bromide

Cat.No: T32066

Synonym: Mylaxen,Hexafluorenium bromide,Milaxen,Hexafluorenium dibromide,Esafluronio bromuro

Cat.No: T71601

Atropine Oxide Hydrochloride

Cat.No: T69232

D-Glucosamine-6-sulfate

Cat.No: T37598

Fondaparinux free base

Cat.No: T71532

Neostigmine Iodide

Cat.No: T33638

Synonym: SB 24,SB24,TL1321,TL 1321,TL-1321,SB-24

Cat.No: T81266

Synonym: GE3126

Cat.No: T25636

Synonym: Laudexium ion,Laudexium cation

Cat.No: T75324

δ14-Triamcinolone acetonide

Cat.No: T35461

Cat.No: T22551

Target: Others

Prostaglandin Bx

Cat.No: T35961

Cat. No.	Product Name	Target	Signaling Pathways
T6060	(±) Anabasine 八角枫碱	Endogenous Metabolite	Metabolism
	(±) Anabasine 是肌肉松弛剂，能够用于外科手术时肌肉松驰。
T19357	Hyaluronidase Hyaluronate 4-glycanohydrolase,Hyaluronoglucosaminidase,透明质酸酶	Others	Others
	Hyaluronidase (Hyaluronate 4-glycanohydrolase) 是一种天然存在的酶，能够分裂糖苷键，使透明质酸解聚。它可用于眼科手术。

天然产物

Cat.No: T6060

Synonym: 八角枫碱

Target: Endogenous Metabolite

Cat.No: T19357

Synonym: Hyaluronate 4-glycanohydrolase,Hyaluronoglucosaminidase,透明质酸酶

Target: Others

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