r 724

R-724 is a bioactive chemical.

UR-7247 是一种新型可口服活性的血管紧张素 II 亚型 I（AT1）受体拮抗剂，具有显著持久的药效。体内研究显示，给药后 4 小时，10 mg UR-7247 与 100 mg losartan 在药效上无显著差异，而体外研究则显示 100 mg losartan 的阻断能力超过 UR-7247，提示 UR-7247 具有较长血浆半衰期，可能与其高亲和力蛋白结合有关，表明其在健康受试者中呈现出长效且耐受性良好的 AT1 阻断作用。

Roccellic acid is a lichen secondary metabolite that has been found in R. montagnei and has antibacterial and anticancer activities.1,2 It is active against the bacteria S. gordonii and P. gingivalis (MIC = 46.9 μg/ml for both).1 Roccellic acid (100 μg/ml) inhibits proliferation of MDA-MB-231, MCF-7, and DLD-1 cancer cells by 65.3, 75.8, and 87.9%, respectively.2 |1. Sweidan, A., Chollet-Krugler, M., Sauvager, A., et al. Antibacterial activities of natural lichen compounds against Streptococcus gordonii and Porphyromonas gingivalis. Fitoterapia 121, 164-169 (2017).|2. Mishra, T., Shukla, S., Meena, S., et al. Isolation and identification of cytotoxic compounds from a fruticose lichen Roccella montagnei, and it's in silico docking study against CDK-10. Rev. Bras. Farmacogn. 27(6), 724-728 (2017).