proteasome inhibitor1

PSI 是蛋白酶体proteasome 抑制剂。它对原发性渗出性淋巴瘤 (PEL) 细胞的增殖具有抑制作用。它可用于 KSHV 相关淋巴瘤、卡波济氏肉瘤相关疱疹病毒 (KSHV) 感染的研究。

Immunoproteasome inhibitor 1 is a highly potent and reversible inhibitor of both immunoproteasome and proteasome activity. It exhibits time-independent inhibitory effects on immunoproteasome subunits β5c, β1i, and β5i, with respective Ki values of 1.18 μM, 0.27 μM, and 1.91 μM. This compound shows promising potential for the treatment of select neoplastic diseases [1].