mglu2/3 receptor

Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2 3 receptor LY404039.

LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2 3 receptor (mGlu2 3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM.

Eglumegad is a highly effective and selective agonist of group II (mGlu2 3) receptor (IC50s: 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively).

CBiPES hydrochloride(CBiPES HCl) 是一种高效的 mGlu2 受体正变构调节剂，EC50值为 92.8 nM。CBiPES hydrochloride 可阻断 WT 和 mGlu（3） 受体的作用。CBiPES hydrochloride 可用于研究像癫痫和帕金森综合征类的神经系统疾病。

LY389795 is an agonist of group II (mGlu2/3) metabotropic glutamate receptor, it is used in inflammatory pain models.

LY3027788, a diester analog of LY3020371, an mGlu2 3 receptor antagonist, is a highly potent and orally active prodrug of LY3020371. Notably, LY3027788 exhibits significant antidepressant efficacy.

LY404039 (pomaglumetad) 是可口服的mGluR2和mGluR3选择性激动剂，有抗精神病和抗焦虑的作用。它对重组人mGluR2和mGluR3的Ki 分别为 149 和 92 nM，比对其他受体 转运蛋白的抑制性高 100 倍以上。

Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) (LY2140023 hydrochloride) 是的 LY404039 的蛋氨酸前药，具有口服活性。LY404039是一种选择性 mGlu2 3 受体激动剂。Pomaglumetad methionil hydrochloride 可用于精神分裂症的研究。

LY2934747 is a novel, potent, and systemically bioavailable mGlu2 3 receptor agonist, exhibiting both antipsychotic and analgesic properties in vivo.

Eglumegad (LY354740) hydrochloride是一种高效且选择性的group II (mGlu2 3) receptor激动剂，其对人mGlu2和mGlu3受体的IC50值分别是5和24 nM。该化合物能够保护神经元不受NMDA毒性影响，并表现出抗焦虑及抗精神病样作用。