gpx-100

GPX-100 is a n analogue of the anthracycline antineoplastic antibiotic doxorubicin. GPX-100 intercalates DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. GPX-100 was designed to be a non-cardiotoxic anthracycline antibiotic. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

GPX-100 (13-deoxydoxorubicin) 是蒽环类抗肿瘤抗生素多柔比星的类似物。GPX-100 插入DNA 并与拓扑异构酶II 相互作用，从而抑制DNA 复制和修复以及RNA 和蛋白质合成。