gpi 1

GPI-1046 是一种无抗生素作用的亲免素配体，部分通过上调 PFC 和 NAc 核心中的谷氨酸转运蛋白 1 来减少乙醇摄入。

GPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiforme, or lymphoma growing at the CNS site. GPI-15427 acts as a potent inhibitor of the enzyme, being capable of inhibiting the activity of purified PARP-1 at nanomolar concentrations. GPI-15427 induced significant sensitization to radiotherapy, representing a promising new treatment in the management of HNSCC.

GPI-1485 (GM1485) 是一种免疫抑制的特异性亲免蛋白配体，可促进中风后的神经功能改善和神经再生。

oxLig-1（7-Ketocholesteryl-9-carboxynonanoate）作为氧化低密度脂蛋白 (oxLDL) 中的关键脂质成分，兼具 β-糖蛋白 I （β(2)-GPI）的主要配体功能。它通过激活NF-κB通路引发核的易位，进而在动脉粥样硬化（AS）的研究中发挥作用。

O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface glycoprotein (VSG), a protein critical for evading the host immune response.1O-11 exhibits essentially no anti-fungal activity when assayed usingC. neoformans, but does have a minor inhibitory effect on HIV-1 replication in T-lymphocytes.3 1.Doering, T.L., Raper, J., Buxbaum, L.U., et al.An analog of myristic acid with selective toxicity for African trypanosomesScience2521851-1854(1991) 2.Doering, T.L., Lu, T., Werbovetz, K.A., et al.Toxicity of myristic acid analogs toward African trypanosomesProceedings of the National Academy of Sciences of the United States of America919735-9739(1994) 3.Langner, C.A., Lodge, J.K., Travis, S.J., et al.4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus IThe Journal of Biological Chemisty267(24)17159-17169(1992)

Vanin-1-IN-2 是vanin-1的有效抑制剂(IC 50 = 162 nM)。Vanin-1 是在肾脏、肝脏和小肠中高水平表达的细胞表面相关的糖基磷脂酰肌醇 (GPI) 锚定蛋白。

Glucose 6-phosphate isomeras (GPI) 葡萄糖 6-磷酸异构酶，即磷酸葡萄糖异构酶 磷酸葡萄糖异构酶 (PGI) 或磷酸己糖异构酶 (PHI)，常用于生化研究。Glucose 6-phosphate isomeras 是一种高度保守的糖酵解酶和二聚酶。Glucose 6-phosphate isomeras 催化葡萄糖-6-磷酸异构成果糖-6-磷酸。

[DAla2, DArg6] Dynorphin A, (1-13) (porcine) (DADAD) 是猪脑垂体提取物中发现的阿片肽（dynorphinl-13, DYN）的一个衍生物。该化合物对GPI和MVD的外周阿片受体有高效力，但在体内易被快速分解。与原始肽相比，[DAla2, DArg6] Dynorphin A, (1-13) (porcine) 更具酶解稳定性，能有效抵抗酶的裂解作用。

[D-Pro2,D-Phe7,D-Trp9]Substance P为Substance P的模拟物，并充当其抑制剂，能间接收缩豚鼠回肠。