erg 1

Ginsenoside Rg1 (Panaxoside Rg1) 是人参的主要活性成分之一，可减少NF-κB 核易位。它改善认知功能受损，通过降低大脑Aβ水平来发挥作用。

PAMAM dendrimer G1.5 carboxylate (PAMAM G1.5 carboxylate) sodium 是一种多聚阴离子树枝状聚合物，由端基羧酸钠组成。在MERS‐CoV斑块抑制试验中，PAMAM dendrimer G1.5 carboxylate 显示出40.5%的抗病毒活性。

NS309 是选择性钙依赖性钾离子通道 SK IK 的激活剂，在 BK 通道上没有激活作用。

Ergtoxin-1为钾离子通道阻断剂，源于墨西哥毒蝎Centruroides noxius的毒液。该化合物具有阻断神经、心脏及内分泌细胞ERG-K+通道的功能。

PF-1163A, a depsipeptide antifungal compound isolated from Penicillium, blocks ergosterol synthesis with an IC50 of 12 ng/ml. This compound specifically inhibits the enzyme ERG25p, a C-4 methyl oxidase in the ergosterol biosynthetic pathway, leading to its antifungal activity. Notably, in Saccharomyces cerevisiae modified to express ERG biosynthesis genes, PF-1163A exhibits an inhibition concentration (MIC value) of 12.5 µg/ml against ERG25p, though strains overexpressing ERG25p show resistance. Additionally, PF-1163A effectively suppresses the growth of Candida albicans (MIC = 8 µg/ml), without affecting other Candida species, Aspergillus fumigatus, or HepG2 cells. Remarkably, it enhances the efficacy of fluconazole against azole-resistant C. albicans strains, showing a significant decrease in MICs (1 and 0.0078 µg/ml alone and in combination, respectively). PF-1163A distinguishes itself from PF-1163B by its more polar nature.