ds 86760016

DS86760016 is a highly effective inhibitor of leucyl-tRNA synthetase (LeuRS), demonstrating potent activity against multidrug-resistant (MDR) Gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Notably, DS86760016 effectively inhibits LeuRS enzymes derived from Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, exhibiting IC50 values of 0.38 μM, 0.62 μM, and 0.16 μM, respectively.

(R)-DS86760016 是 DS86760016 的 R 对映体，是一种亮氨酸-tRNA 合成酶 (LeuRS) 抑制剂，对大肠杆菌、肺炎克雷伯菌和铜绿假单胞菌等多药耐药 (MDR) 革兰氏阴性菌具有抗菌活性。