doxazosin d8

Doxazosin D8 (UK 33274 D8) is a deuterium labeled Doxazosin (UK 33274).Doxazosin, a quinazoline derivative, selectively antagonizes postsynaptic AP1 adrenergic receptor.

(R)-Doxazosin ((R)-UK 33274) 是 Doxazosin 的异构体，一种选择性口服a1-肾上腺素能受体 (a1-adrenoceptor) 激动剂。Doxazosin 用于全身性抗高血压和眼部降压。通过选择性拮抗突触后 a1 受体，减少整体外周阻力，达到抗高血压效果，无心输出量降低。它显著降低站立及卧位血压。

Doxazosin (UK 33274) 是选择性的拮抗突触后的α1肾上腺素受体。

Doxazosin HCl is the salt form of Doxazosin Free Base which acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.

Doxazosin mesylate (UK 33274 mesylate) 是一种喹唑啉衍生物。它是一种选择性拮抗突触后α1-肾上腺素能受体。