dbco-peg-5-dbco

DBCO-PEG5-DBCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG5-NHS ester is a polyethylene glycol (PEG)-based linker utilized in the synthesis of PROTACs[1].

DBCO-PEG5-NHS ester 是一种属于 PEG 类和 Alkyl ether 类的 PROTAC linker，用于合成一系列 PROTAC 分子。

DOTA-PEG5-C4-DBCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PROTAC BRD4 Degrader-5-CO-PEG3-N3 (Compound 2) 是一款专为 PAC 设计的PROTAC-linker偶联物,采用了含有BRD4降解剂GNE-987的构造,并通过3个PEG的linker进行连接.该化合物也是一种效率高的点击化学试剂,内含Azide基团,可通过铜催化的叠氮-炔环加成反应(CuAAc)与含Alkyne基团的分子反应.此外,它还能通过与含DBCO或BCN基团的分子进行菌株促进的炔-叠氮环加成反应(SPAAC)进行反应.