concanamycin a

Concanamycin A (Folimycin) 是一种多聚环内酯类抗生素，是选择性空泡状 H+-ATP 酶 (V-ATPase) 和溶酶体酸化抑制剂，可用于研究炎症。Concanamycin A 可增强细胞毒性 T 淋巴细胞对受感染原代细胞的免疫清除，抑制来自 HIV 和猿猴免疫缺陷病毒不同分支的 Nef 等位基因，可用于研究HIV 感染。

Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). In this way, it blocks the acidification of vacuolar organelles as well as early to late endosomal transport. Concanamycin B interferes with bone resorption and maturation of CD8 T lymphocytes. It also prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting the expression of MHC class II molecules on the cell surface.

Concanamycin F 是一种 V 型 ATPase 的特异性抑制剂 (Ki=0.02 nM)，展现出抗真菌、抗病毒、免疫抑制和细胞毒等多种活性。

Concanamycin C, a natural macrolide antibiotic, was initially isolated from Streptomyces and identified as an inhibitor of T-cell proliferation in response to concanavalin A (1,2). It exhibits cytotoxicity to fungi, including yeasts, by inhibiting vacuolar-type ATPases (3,4).

Concanamycin G 是 V 型 ATPase 的特异性抑制剂（Ki=0.02 nM），并表现出抗真菌、抗病毒、免疫抑制和细胞毒等活性。

Concanamycin E 是一种抑制溶酶体酸化 (lysosomal acidification) 的化合物，其 IC50 为 0.085 nM。

Concanamycin D 是一种溶酶体酸化抑制剂，其IC50值为0.085 nM。