calmodulin antagonist 1

Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist that effectively inhibits calmodulin-activated Ca 2+ -phosphodiesterase (PDE) with an IC 50 of 28 μM. This compound also competitively inhibits trypsin-treated Ca 2+ -PDE with respect to cyclic GMP, exhibiting an IC 50 of 375 μM and a K i value of 300 μM.

W-5 hydrochloride (N-(6-Aminohexyl)-1-naphthalenesulfonamide HCl) 一种有效的钙调素拮抗剂。

CALP2 TFA 是一种钙调蛋白 (CaM) 拮抗剂 (Kd 为 7.9 µM)，以亲和力结合CaMEF-hand Ca2+结合位点。CALP2 TFA 抑制CaM 依赖性磷酸二酯酶 (phosphodiesterase) 活性并增加细胞内 Ca2+浓度。CALP2 TFA 有效抑制粘附和脱粒。CALP2 TFA 还是肺泡巨噬细胞的强激活剂。

Calmodulin-Dependent Protein Kinase II (290-309) acetate 是有效的 CaMK 拮抗剂， 抑制抑制 Ca2+ 钙调蛋白依赖性蛋白激酶II 的IC50值为52 nM。