boc-nh-peg2-nh-boc

Boc-NH-PEG2-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-PEG2-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Amino-PEG2-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Biotin-PEG2-NH-Boc is a PEG-based PROTAC linker labelled with biotin, which enables its application in PROTAC synthesis[1].

Boc-NH-PEG2-C2-NHS ester is an alkyl ether-derived PROTAC linker employed for the synthesis of PROTACs[1].

Boc-NH-PEG2-CH2CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Boc-NH-PEG2-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Boc-NH-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Bromoacetamido-C2-PEG2-NH-Boc is a polyethylene glycol (PEG)-based linker with a bromoacetamido functional group and a tert-butoxycarbonyl (Boc) protecting group. It serves as an integral component in the synthesis of proteolysis-targeting chimeras (PROTACs), which are innovative compounds used for targeted protein degradation[1].

Mal-PEG2-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-Mal-N-bis(PEG2-NH-Boc) is a polyethylene glycol (PEG) derived linker specifically designed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

NH-bis(C2-PEG2-NH-Boc) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

NH-bis(PEG2-C2-Boc) is an alkyl ether-based linker, utilized for the synthesis of PROTACs[1].

NH2-PEG2-C2-Boc is a polyethylene glycol (PEG)-based PROTAC linker utilized for synthesizing PROTACs[1]. It serves as a non-cleavable 2-unit PEG linker for antibody-drug conjugates (ADCs) in their synthesis[2].

Boc-NH-PEG2 (PROTAC Linker 11) is a polyethylene glycol (PEG)-based linker that finds application in the synthesis of PROTACs. [1]

Boc-NH-PEG2-C2-NH2 (PROTAC Linker 13) is a PEG-based linker utilized for the synthesis of PROTACs. This chemical compound plays a crucial role in connecting the targeted protein and the E3 ubiquitin ligase for selective protein degradation[1].

DBCO-PEG2-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc is a novel synthesized conjugate compound functioning as an E3 ligase ligand-linker in PROTAC technology. This compound incorporates a Pomalidomide-derived cereblon ligand, which binds selectively to the E3 ligase cereblon, and a 2-unit PEG linker, which provides stability and flexibility to the conjugate.

N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a polyethylene glycol (PEG)-based linker for the development of proteolysis targeting chimeras (PROTACs)[1].

Boc-NH-PEG2-C2-amido-C4-acid (PROTAC Linker 30) is a polyethylene glycol (PEG)-based linker utilized for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Tos-PEG2-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

JB300 是一种利用PROTAC技术的Aurora A高选择性降解剂（DC50=30 nM），用于肿瘤研究。JB300 由PROTAC靶蛋白配体MK-5108 (pink part)、E3连接酶配体Thalidomide-O-COOH (blue part) 及PROTAC Linker Boc-NH-PEG2-C2-NH2 (black part) 组成，其中E3泛素连接酶配体与Linker的结合物为Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc。

Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc 是一种包含 E3 连接酶配体和连接子的偶联物，结合了基于 Thalidomide 的 CEREBLON 配体和一个 PEG linker。此化合物可以用于合成 PROTAC 降解剂 JB300。

NH2-PEG2-CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.