acid-sensing ion channel (asic)

GMQ hydrochloride (NSC-403387 hydrochloride) 是一种有效的选择性酸感应离子通道 (ASIC) 调节剂。它在中性 pH 值下激活 ASIC3 通道并阻止酸引起的最大峰值电流。

A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM, and it has antidepressant and antinociception effects[1][2].

ASIC-IN-1 是一种有效的酸感应离子通道 (acid sensing ion channel) 抑制剂，IC50值为 < 10 μM。ASIC-IN-1 导致疼痛强度的剂量依赖性降低。