a 924

A 924 is an amino acid derivative with antineoplastic activity.

PR-924 is a selective inhibitor of tripeptide epoxyketone immunoproteasome subunit LMP-7 (IC50: 22 nM). PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities. PR-924 covalently modifies proteasomal N-terminal threonine active sites.

CI 924 is a lipid-lowering drug. CI 924 increased anti-atherosclerotic HDL and decreased VLDL at 600 mg day.

UCSF924 is a potent and specific agonist of dopamine D4 receptor (DRD4) partial (EC50: 4.2 nM, Ki: 3 nM).

UCSF924NC is the recommended negative control compound for the high-affinity dopamine D4 receptor (DRD4) partial agonist UCSF924. UCSF924NC exhibits a 1 2500-fold reduced D4 affinity when compared with that of UCSF924.

Anti-VEGF165 VEGFA Antibody (5L924) 是一种靶向人 VEGF165 VEGFA 的单克隆抗体，是一种 Rabbit IgG 抗体。

KZR-616, a first-in-class inhibitor of the immunoproteasome, selectively targets the LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50: 131/179 nM=hLMP7/mLMP7) subunits of the immunoproteasome. KZR-616 has the potential for the research of multiple autoimmune diseases[1][2]. KZR-616 also inhibits MECL-1 subunit (IC50=623 nM) and constitutive proteasome β5 subunit (IC50=688 nM). KZR-616 maintains LMP7 and LMP2 selective inhibition in MOLT-4 cells. KZR-616 (250 nM) shows a comparable cytokine inhibition profile peripheral blood mononuclear cells (PBMC)[1].KZR-616 is an immunoproteasome-selective inhibitor identified based on the optimization of ONX-0914 and PR-924 [3]. KZR-616 (5 mg/kg; i.v.; dosing was repeated on days 6, 8, 11, and 13) shows efficacy in the anticollagen antibody induced arthritis (CAIA) model[1]. [1]. Johnson HWB, et al. Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide). J Med Chem. 2018 Dec 27;61(24):11127-11143. [2]. Muchamuel T, et al. FRI0296 Kzr-616, a selective inhibitor of the immunoproteasome, blocks the disease progression in multiple models of systemic lupus erythematosus (SLE). Annals of the Rheumatic Diseases 2018;77:685. [3]. Xi J, et al. Immunoproteasome-selective inhibitors: An overview of recent developments as potential drugs for hematologic malignancies and autoimmune diseases. Eur J Med Chem. 2019;182:111646.

Ethyl 3-(dimethylamino)acrylate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66876，CAS号为 924-99-2。

ZZM-1220是一种针对组蛋白赖氨酸甲基转移酶G9a GLP的共价抑制剂，IC50值分别为458 nM和924 nM。该化合物能有效抑制H3K9me2在细胞中的作用，从而显著促进三阴性乳腺癌(TNBC)细胞的凋亡(apoptosis)，同时在G2 M期阻断细胞周期的进程。

N-Nitroso-Di-n-Butylamine-d18 是 N-Nitroso-Di-n-Butylamine 的氘代化合物。N-Nitroso-Di-n-Butylamine 的 CAS 号为 924-16-3。