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Search Results for " dnp "

53

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1682L	Abz-FR-K(Dnp)-P-OH acetate Abz-FR-K(Dnp)-P-OH acetate (500799-61-1 free base)	Others	Others
	Abz-FR-K(Dnp)-P-OH acetate(500799-61-1 free base) 是一种出色的血管紧张素 I 转换酶 (ACE) 底物，Km 值为 4.0 μM，kcat 值为 210s-1。
T18983	DNP-X acid 6-((2,4-Dinitrophenyl)amino)hexanoic acid	Others	Others
	DNP-X acid (6-((2,4-Dinitrophenyl)amino)hexanoic acid) 是一种与 Trp 或 Tyr 配对的极好的胺反应性 FRET 淬灭剂，能够用于开发可被 anti-DNP 抗体识别的探针的胺反应性构建块。
T18984	DNP-X, SE 6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester	Others	Others
	DNP-X, SE (6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester) 是一种用于开发可被 anti-DNP 抗体识别的探针的胺反应性构建块，是经过琥珀酰亚胺酯修饰的 DNP-X acid。它也是一种能够与 Trp 或 Tyr 配对的极好的胺反应性 FRET 淬灭剂。
T17841	DNP-PEG6-Boc DNP-PEG6-t-butyl ester	Others	Others
	DNP-PEG6-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15151	DNP-PEG3-DNP	Others	Others
	DNP-PEG3-DNP is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T36792	DNP-INT
	DNP-INT is a quinone analog that inhibits electron transport in plants by competitively inhibiting plastoquinol oxidation by binding at the Qo site of cytochrome b6f (Kd = 1.4 nM). It inhibits electron flow from water to NADP or methylviologen by 50 and 100% when used at concentrations of 0.5 or 5 μM, respectively.
T37024	Mca-DEVDAPK(Dnp)-OH
	Mca-DEVDAPK(Dnp)-OH 是 caspase-3 的荧光底物。
T36363	Dnp-RPLALWRS (trifluoroacetate salt)
	Dnp-RPLALWRS is a fluorogenic substrate for matrix metalloproteinase-7 (MMP-7). The activity of MMP-7 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group.
T38378	Dnp-PLAYWAR (trifluoroacetate salt)
	Dnp-PLAYWAR is a fluorogenic substrate for matrix metalloproteinase-8 (MMP-8) and MMP-26. The activity of MMP-8 and MMP-26 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group.
T36361	Dnp-PLALWAR (trifluoroacetate salt)
	Dnp-PLALWAR is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-8. The activity of MMP-1 and MMP-8 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group.
T36362	Dnp-PLGMWSR (trifluoroacetate salt)
	Dnp-PLGMWSR is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-9. The activity of MMP-2 and MMP-9 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group.
T36360	Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2
	Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9. Upon cleavage by MMP-1 or MMP-9, N-methylanthranilic acid (Nma) is unquenched and its fluorescence can be used to quantify MMP activity. Nma displays excitation/emission spectra of 340/440 nm, respectively.
T17837	DNP-PEG12-acid	Others	Others
	DNP-PEG12-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17839	DNP-PEG4-DBCO	Others	Others
	DNP-PEG4-DBCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17840	DNP-PEG6-acid	Others	Others
	DNP-PEG6-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15153	DNP-PEG4-alcohol	Others	Others
	DNP-PEG4-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15150	DNP-PEG3-azide	Others	Others
	DNP-PEG3-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15152	DNP-PEG4-acid	Others	Others
	DNP-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15148	DNP-NH-PEG2-C2-acid	Others	Others
	DNP-NH-PEG2-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15154	DNP-PEG4-NHS ester	Others	Others
	DNP-PEG4-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17838	DNP-PEG12-NHS ester	Others	Others
	DNP-PEG12-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T40384	Mca-Ala-Pro-Lys(Dnp)-OH
	Mca-Ala-Pro-Lys(Dnp)-OH, a specific quenched fluorogenic substrate for ACE2, enables the detection of ACE2 activity in various tissues including urinary, heart, and lung.
TP1505	MCA-SEVNLDAEFR-K(Dnp)-RR, amide
	MCA-SEVNLDAEFR-K(Dnp)-RR, amide is a FRET-based substrate.
T15149	DNP-NH-PEG4-C2-Boc	Others	Others
	DNP-NH-PEG4-C2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
TP1634	Bacterial Sortase Substrate III, Abz/DNP
	The Staphylococcus aureus transpeptidase Sortase A (SrtA) anchors virulence and colonization-associated surface proteins to the cell wall. SrtA selectively recognizes a C-terminal LPXTG motif. SrtA readily reacts with its native substrate Abz-LPETG-Dap(DN
TP1682	Abz-FR-K(Dnp)-P-OH
	Excellent angiotensin I-converting enzyme (ACE) substrate with a Km value of 4.0 μM and a kcat value of 210s-1.
TP1322	Bacterial Sortase Substrate III, Abz/DNP (TFA)
	Bacterial Substrate III, Abz/DNP TFA is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the f
T31660	epsilon-Dinitrophenyllysine Dinitrophenyl-lysine,Epsilon-dnp-lysine
	epsilon-Dinitrophenyllysine is a bioactive chemical.
T81720	N,N'-Dinitrosopiperazine 1,4-Dinitrosopiperazine,DNP
	N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) 为已知致癌物，与鼻咽癌发展及其转移关联。该化合物通过影响包括LYRIC在内的多条信号通路，特别是通过蛋白磷酸化作用于丝氨酸568位，发挥作用。
T76090	Mca-YVADAP-Lys(Dnp)-OH
	Mca-YVADAP-Lys(Dnp)-OH 是caspase-1和血管紧张素转换酶 2 (ACE2) 的荧光底物。
T76269	Dnp-PLGLWA-DArg-NH2 TFA
	Dnp-PLGLWA-DArg-NH2 TFA 作为MMP-1和MMP-9的荧光底物，能够用于定量测定MMPs的活性（Ex=280 nm, Em=360 nm）。
T81836	Mca-SEVNLDAEFK(Dnp)-NH2
	Mca-SEVNLDAEFK(Dnp)-NH2具备一个7-甲氧基香豆素（Mca）荧光基团，由于其与2,4-二硝基苯基（Dnp）间的共振能量转移作用，荧光得到有效猝灭。该化合物主要应用于检测切割Mca与Dnp之间酰胺键的肽酶活性，如BACE-1，其活性导致荧光增强。
T83687	Mca-RPPGFSAFK(Dnp)-OH TFA (7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(2,4-dinitrophenyl)-OH
	Mca-RPPGFSAFK(Dnp)-OH 是 endothelin-converting enzyme-1 (ECE-1) 的一种荧光底物。当 ECE-1 切割该底物时，会释放 7-methoxycoumarin-4-acetyl (Mca)，其荧光可以用来量化 ECE-1 的活性。Mca 的激发/发射峰值分别为 328/420 nm。
T78435	Mca-(ala7,lys(dnp)9)-bradykinin
	Mca-(ala7,lys(dnp)9)-bradykinin是一种具备高灵敏度的ECE-1（内皮素转化酶-1）荧光底物，通过引入(7-甲氧基香豆素-4-基)乙酰基(Mca)作为荧光基团与2,4-二硝基苯(Dnp)作猝灭基团，使得在酶作用下底物发生裂解时，荧光强度明显提升。
T76268	Mca-VDQVDGW-Lys(Dnp)-NH2
	Mca-VDQVDGW-Lys(Dnp)-NH2 是 caspase-7 的荧光底物。可用于定量 caspase-7 活性。
T78430	Bacterial Sortase Substrate III, Abz/DNP TFA
	BacterialSortase Substrate III, Abz/DNP TFA是一种用于检测金黄色葡萄球菌转肽酶分选酶A (SrtA) 活性的内部淬灭荧光肽底物。当SrtA与此底物反应时，会催化苏氨酸的羧基与细胞壁交联桥的氨基形成酰胺键，并导致该底物在Ex/Em=320 nm/420 nm下被裂解，可以通过该波长检测其裂解情况。
T80048	Mca-YVADAP-Lys(Dnp)-OH TFA
	Mca-YVADAP-Lys(Dnp)-OH TFA为Caspase-1及血管紧张素转换酶2(ACE2)特异性的荧光底物。
T83686	Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 acetate
	Mca-SEVNLDAEFR-K(Dnp)-RR-NH2是β-分泌酶(BACE)的荧光底物。当BACE切割该底物时，7-甲氧基香豆素-4-乙酰基(Mca)会被释放出来，其荧光可用于定量BACE活性。Mca的激发/发射最大值分别为328/420 nm。
T83719	Mca-AVLQSGFR-K(Dnp)-K-NH2 TFA
	Mca-AVLQSGFR-K(Dnp)-K-NH2 是针对严重急性呼吸综合征冠状病毒(SARS-CoV)主蛋白酶(Mpro)，也称为3C样蛋白酶(3CLpro)的荧光底物。SARS-CoV Mpro 切割后，会释放7-甲氧基香豆素-4-乙酰基(Mca)，通过其荧光可以量化SARS-CoV Mpro 活性。Mca 的激发/发射波长最大值分别为328/420 nm。
T83759	MMP-3 Fluorogenic Substrate TFA Mca-RPKPVE-Nval-WR-K(Dnp)-NH2,Matrix Metalloproteinase-3 Fluorogenic Substrate,Stromelysin-1 Fluorogenic Substrate
	MMP-3 fluorogenic substrate 是一种针对基质金属蛋白酶-3（MMP-3）的荧光底物。当被MMP-3切割后，7-甲氧基香豆素-4-乙酰基（Mca）会释放并且其荧光可用于量化MMP-3活性。Mca的激发/发射峰值分别为328/420 nm。
T83708	Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 (Dpa = N-3-(2,4-dinitrophenyl)l-α,β-diaminopropionyl),FS-6
	Mca-KPLGL-Dap(Dnp)-AR-NH2是一种用于矩阵金属蛋白酶(MMPs)的荧光底物。当被MMPs切割时，7-甲氧基香豆素-4-乙酰基(Mca)会释放，其荧光可用来定量MMP活性。Mca的激发/发射峰值分别为328/420 nm。
T76190	Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2
	Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 是一种荧光底物，主要用于测定基质金属蛋白酶-1 (MMP-1)、MMP-3 和MMP-26的活性。
T81838	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human)
	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) 为一种基于FRET (荧光共振能量转移) 原理的多肽底物，通过其裂解引起的荧光强度变化来评估其活性。
T78436	Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2	MMP	Proteases/Proteasome
	Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) 是一种用于实时定量测定基质金属蛋白酶(MMP)酶活性的猝灭荧光肽底物。该化合物是MMP底物(FS-1)的衍生物，对胶原酶MMP-1、MMP-8、MMP-13及MT1-MMP的特异性常数更高，具备较强的底物特异性。荧光激发与发射波长分别为325 nm和400 nm。
T78434	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA
	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA 为基于荧光共振能量转移的多肽底物，通过裂解引起的荧光强度变化来确定其活性。
T37504	Cathepsin D and E FRET Substrate
	Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.
T7570	RGD peptide (GRGDNP) RGD peptide GRGDNP(2TFA),H-甘氨酰-精氨酰-甘氨酰-天冬氨酰-天冬酰胺酰-脯氨酸-OH,RGD peptide GRGDNP	Apoptosis; Integrin	Apoptosis; Cytoskeletal Signaling
	RGD peptide (GRGDNP) (RGD peptide GRGDNP(2TFA)) 是一种整合素-配体相互作用的抑制剂，通过激活构象变化促进细胞凋亡，从而增强 caspase-3的活化，在细胞黏附、迁移、生长和分化中发挥重要作用。
T76007	RGD peptide (GRGDNP) (TFA)
	RGD peptide (GRGDNP) TFA 作为整合素-配体之间相互作用的竞争性抑制剂，阻碍α5β1与细胞外基质(ECM)的结合，并通过激活增强pro-caspase-3的自我加工和构象变化来促进细胞凋亡。该化合物在细胞粘附、迁移、生长和分化等过程中扮演着关键角色。
TP1311	RGD peptide (GRGDNP) (TFA) (114681-65-1 free base) RGD peptide (GRGDNP) (TFA)
	RGD peptide (GRGDNP) (TFA) promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing.
T36340	Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp (trifluoroacetate salt)
	Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM-1s-1). Enzymatic peptide hydrolysis disrupts the Abz:EDDnp donor-acceptor pair allowing fluorescence measurement of Abz (ex = 320 nm; em = 420 nm).

化合物

Abz-FR-K(Dnp)-P-OH acetate

Cat.No: TP1682L

Synonym: Abz-FR-K(Dnp)-P-OH acetate (500799-61-1 free base)

Target: Others

Cat.No: T18983

Synonym: 6-((2,4-Dinitrophenyl)amino)hexanoic acid

Target: Others

Cat.No: T18984

Synonym: 6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester

Target: Others

Cat.No: T17841

Synonym: DNP-PEG6-t-butyl ester

Target: Others

DNP-PEG3-DNP

Cat.No: T15151

Target: Others

Cat.No: T36792

Mca-DEVDAPK(Dnp)-OH

Cat.No: T37024

Dnp-RPLALWRS (trifluoroacetate salt)

Cat.No: T36363

Dnp-PLAYWAR (trifluoroacetate salt)

Cat.No: T38378

Dnp-PLALWAR (trifluoroacetate salt)

Cat.No: T36361

Dnp-PLGMWSR (trifluoroacetate salt)

Cat.No: T36362

Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2

Cat.No: T36360

Synonym: Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2

DNP-PEG12-acid

Cat.No: T17837

Target: Others

DNP-PEG4-DBCO

Cat.No: T17839

Target: Others

DNP-PEG6-acid

Cat.No: T17840

Target: Others

DNP-PEG4-alcohol

Cat.No: T15153

Target: Others

DNP-PEG3-azide

Cat.No: T15150

Target: Others

DNP-PEG4-acid

Cat.No: T15152

Target: Others

DNP-NH-PEG2-C2-acid

Cat.No: T15148

Target: Others

DNP-PEG4-NHS ester

Cat.No: T15154

Target: Others

DNP-PEG12-NHS ester

Cat.No: T17838

Target: Others

Mca-Ala-Pro-Lys(Dnp)-OH

Cat.No: T40384

MCA-SEVNLDAEFR-K(Dnp)-RR, amide

Cat.No: TP1505

DNP-NH-PEG4-C2-Boc

Cat.No: T15149

Target: Others

Bacterial Sortase Substrate III, Abz/DNP

Cat.No: TP1634

Abz-FR-K(Dnp)-P-OH

Cat.No: TP1682

Bacterial Sortase Substrate III, Abz/DNP (TFA)

Cat.No: TP1322

epsilon-Dinitrophenyllysine

Cat.No: T31660

Synonym: Dinitrophenyl-lysine,Epsilon-dnp-lysine

N,N'-Dinitrosopiperazine

Cat.No: T81720

Synonym: 1,4-Dinitrosopiperazine,DNP

Mca-YVADAP-Lys(Dnp)-OH

Cat.No: T76090

Dnp-PLGLWA-DArg-NH2 TFA

Cat.No: T76269

Mca-SEVNLDAEFK(Dnp)-NH2

Cat.No: T81836

Mca-RPPGFSAFK(Dnp)-OH TFA

Cat.No: T83687

Synonym: (7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(2,4-dinitrophenyl)-OH

Mca-(ala7,lys(dnp)9)-bradykinin

Cat.No: T78435

Mca-VDQVDGW-Lys(Dnp)-NH2

Cat.No: T76268

Bacterial Sortase Substrate III, Abz/DNP TFA

Cat.No: T78430

Mca-YVADAP-Lys(Dnp)-OH TFA

Cat.No: T80048

Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 acetate

Cat.No: T83686

Mca-AVLQSGFR-K(Dnp)-K-NH2 TFA

Cat.No: T83719

MMP-3 Fluorogenic Substrate TFA

Cat.No: T83759

Synonym: Mca-RPKPVE-Nval-WR-K(Dnp)-NH2,Matrix Metalloproteinase-3 Fluorogenic Substrate,Stromelysin-1 Fluorogenic Substrate

Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA

Cat.No: T83708

Synonym: Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 (Dpa = N-3-(2,4-dinitrophenyl)l-α,β-diaminopropionyl),FS-6

Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2

Cat.No: T76190

Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human)

Cat.No: T81838

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2

Cat.No: T78436

Target: MMP

Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA

Cat.No: T78434

Cathepsin D and E FRET Substrate

Cat.No: T37504

RGD peptide (GRGDNP)

Cat.No: T7570

Synonym: RGD peptide GRGDNP(2TFA),H-甘氨酰-精氨酰-甘氨酰-天冬氨酰-天冬酰胺酰-脯氨酸-OH,RGD peptide GRGDNP

Target: Apoptosis, Integrin

RGD peptide (GRGDNP) (TFA)

Cat.No: T76007

RGD peptide (GRGDNP) (TFA) (114681-65-1 free base)

Cat.No: TP1311

Synonym: RGD peptide (GRGDNP) (TFA)

Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp (trifluoroacetate salt)

Cat.No: T36340

Cat. No.	Product Name	Target	Signaling Pathways
T3926	Echinatin 刺甘草查尔酮,Retrochalcone	Free radical scavengers	oxidation-reduction
	Echinatin (Retrochalcone) 是分离自中草药甘草中，具有保肝和抗炎活性。在大鼠中，它可以被快速吸收和消除，并广泛分布，绝对生物利用度约为 6.81％。
TN2155	Rhodiocyanoside A	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Rhodiocyanoside A has antiallergic activity, it exhibits inhibitory activity on the histamine release from rat peritoneal exudate cells sensitized with anti-DNP IgE and inhibits the PCA reaction in rats.
TN3914	Echinatine	ATPase; IL Receptor; TNF	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel
	Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory activities of this compound. Echinatin can inhibit DNP-ATPase activity whil

天然产物

Cat.No: T3926

Synonym: 刺甘草查尔酮,Retrochalcone

Target: Free radical scavengers

Rhodiocyanoside A

Cat.No: TN2155

Target: Histamine Receptor

Cat.No: TN3914

Target: ATPase, IL Receptor, TNF

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