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SRSF3 Protein, Human, Recombinant (GB1 & His)

SRSF3 Protein, Human, Recombinant (GB1 & His)

产品编号 TMPH-02086

SRSF3 Protein, Human, Recombinant (GB1 & His) is expressed in E. coli.

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SRSF3 Protein, Human, Recombinant (GB1 & His)
规格 价格/CNY 货期 数量
20 μg ¥ 1,800 20日内发货
100 μg ¥ 3,420 20日内发货
1 mg ¥ 14,600 20日内发货
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产品目录号及名称: SRSF3 Protein, Human, Recombinant (GB1 & His) (TMPH-02086)
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生物活性
技术参数
产品性质
产品描述 SRSF3 Protein, Human, Recombinant (GB1 & His) is expressed in E. coli.
种属 Human
表达系统 E. coli
标签 N-6xHis-GB1
蛋白编号 P84103
氨基酸序列 MHRDSCPLDCKVYVGNLGNNGNKTELERAFGYYGPLRSVWVARNPPGFAFVEFEDPRDAADAVRELDGRTLCGCRVRVELSNGEKR
蛋白构建 1-86 aa
蛋白纯度 > 90% as determined by SDS-PAGE.
分子量 17.9 kDa (predicted)
缓冲液 If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Splicing factor that specifically promotes exon-inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. Also functions as export adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. RNA-binding is semi-sequence specific.

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Keywords

recombinant recombinant-proteins proteins protein

 

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