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Neurofascin Protein, Human, Recombinant (hFc), Biotinylated

产品编号 TMPY-05268

别名: NRCAML, neurofascin, NF

Neurofascin Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 130 kDa and the accession number is O94856-9.

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Neurofascin Protein, Human, Recombinant (hFc), Biotinylated

规格	价格/CNY		货期	数量
20 μg	￥ 1,950		5日内发货
100 μg	￥ 4,620		5日内发货

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生物活性	Testing in progress
产品描述	Neurofascin Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 130 kDa and the accession number is O94856-9.

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	O94856-9
别名	NRCAML, neurofascin, NF
蛋白构建	The Human NFASC (NP_001005388.2) (Met1-Gln939) was expressed with the Fc region of Human IgG1 at the C-terminus. The purified protein was biotinylated in vitro.
蛋白纯度	> 90 % as determined by SDS-PAGE.
分子量	130 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	NFASC (Neurofascin, also known as NRCAML, NEDCPMD, and NF) is a Protein Coding gene. 13 alternatively spliced human isoforms have been reported. NFASC belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM family. It contains 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. NFASC links the AIS extracellular matrix to the intracellular cytoskeleton. It is broadly expressed in the brain, kidney, and other tissues. Diseases associated with NFASC include Neurodevelopmental Disorder With Central And Peripheral Motor Dysfunction and Demyelinating Polyneuropathy.

参考文献

1. Volkmer H. et al., 1992, J Cell Biol. 118 (1): 149-61. 2. Burmeister M. et al., 1996, Mamm Genome. 7 (7): 558-9. 3. Ango F. et al., 2004, Cell. 119 (2): 257-72.

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Keywords

Neurofascin Protein, Human, Recombinant (hFc), Biotinylated NRCAML neurofascin NF recombinant recombinant-proteins proteins protein

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