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IL-17RA Protein, Rhesus, Recombinant (hFc)

产品编号 TMPY-03214
IL-17RA Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 60.3 kDa and the accession number is XP_001102483.1.
规格价格库存数量
100 μg
¥ 4,460
5日内发货
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产品信息

生物活性
Immobilized human IL17A at 10 μg/ml (100 μl/well) can bind Rhesus IL17RA-Fc, The EC50 of Rhesus IL17RA-Fc is 0.19-0.43 μg/ml.
产品描述
IL-17RA Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 60.3 kDa and the accession number is XP_001102483.1.
种属
Rhesus
表达系统
HEK293 Cells
标签C-hFc
蛋白编号XP_001102483.1
别名
interleukin 17 receptor A
蛋白构建
A DNA sequence encoding the rhesus IL17RA (XP_001102483.1) (Met1-Trp320) was expressed, fused with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Leu 33
蛋白纯度
> 90 % as determined by SDS-PAGE
分子量60.3 kDa (predicted)
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式In general, Lyophilized powders are shipping with blue ice.
研究背景
Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor that binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails, and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.

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