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CCL20 Protein, Mouse, Recombinant (His)

产品编号 TMPY-02770

别名: CKb4, exodus-1, MIP-3[a], ST38, MIP3A, LARC, MIP-3A, chemokine (C-C motif) ligand 20, Scya20

CCL20 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 9.3 kDa and the accession number is O89093-1.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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CCL20 Protein, Mouse, Recombinant (His)

规格	价格/CNY		货期	数量
50 μg	￥ 3,930		5日内发货

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生物活性	Testing in progress
产品描述	CCL20 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 9.3 kDa and the accession number is O89093-1.

种属	Mouse
表达系统	Baculovirus Insect Cells
标签	C-His
蛋白编号	O89093-1
别名	CKb4, exodus-1, MIP-3[a], ST38, MIP3A, LARC, MIP-3A, chemokine (C-C motif) ligand 20, Scya20
蛋白构建	The Mouse CCL20 (O89093-1) (Met 1-Met 97) was expressed，with a C-terminal polyhistidine tag.
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	9.3 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 500 mM NaCl, pH 7.4, 10% gly. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family that attracts immature dendritic cells and memory T lymphocytes, both expressing CCR6. Depending on the cell type, this chemokine was found to be inducible by cytokines (IL-1beta) and by bacterial, viral, or plant products (including LPS, dsRNA, and PMA). MIP3A / CCL20 is Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels of MIP3A / CCL20 has been seen in thymus, prostate, testis, small intestine and colon. As a chemotactic factor, MIP3A / CCL20 attracts lymphocytes and, slightly, neutrophils, but not monocytes. This chemokine may Inhibit proliferation of myeloid progenitors in colony formation assays and it may be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. Its C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Chemokine CCL20 was shown to play a role in colorectal cancer (CRC) pathogenesis.

参考文献

1. Vicinus B,et al.(2012) miR-21 functionally interacts with the 3'UTR of chemokine CCL20 and down-regulates CCL20 expression in miR-21 transfected colorectal cancer cells. Cancer Lett. 316(1): 105-12. 2. Ding X,et al.(2012) High Expression of CCL20 Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma after Curative Resection. J Gastrointest Surg. 16(4): 828-36. 3. Ivison SM,et al.(2010) Oxidative stress enhances IL-8 and inhibits CCL20 production from intestinal epithelial cells in response to bacterial flagellin. Am J Physiol Gastrointest Liver Physiol. 299(3): 733-41.

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Keywords

CCL20 Protein, Mouse, Recombinant (His) ST 38 CKb4 exodus-1 ST-38 MIP-3[a] ST38 MIP3A LARC MIP-3A chemokine (C-C motif) ligand 20 Scya20 recombinant recombinant-proteins proteins protein

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