Name: Risankizumab
Brand: TargetMol
SKU: T76778
Price: 4820 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 4,820

现货

5 mg

¥ 9,960

现货

10 mg

¥ 13,300

现货

生物活性

产品描述	Risankizumab (BI 655066) is a humanized IgG monoclonal antibody (Kd <10 pM) targeting the IL-23 p19 subunit. Risankizumab inhibits IL-17 production induced by human IL-23 in mouse splenocytes with an IC50 value of 2 pM.Risankizumab is used for the prevention and treatment of immune and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis, and erythrodermic psoriasis.
靶点活性	IL-23:10pM (kd,cynomolgus), IL-17:2 pM (human), IL-17:17 pM (cynomolgus), IL-23:10pM (kd,human)
体外活性	Risankizumab (BI 655066) 对人类及猕猴IL23[3]显示出高度亲和力，Kds<10 pM。同时，Risankizumab (BI 655066) 能够抑制内源性（由THP-1细胞产生）和重组猕猴IL23诱导的人IL17产生，其IC50分别为2 pM和17 pM[2]。
体内活性	在小鼠中，Risankizumab (BI 655066) 在单次腹腔内（i.p.）给药，剂量为1 mg/kg[2]后，可抑制IL23引起的耳部肿胀和细胞因子产生。
别名	利散吉珠单抗, SKYRIZI, Risankizumab rzaa, BI-655066, ABBV 066
反应种属	Human
验证活性	Immobilized Human IL-23 Protein (His) (TMPY-00406) at 1 μg/mL (100 μL/well) can bind Risankizumab. The EC50 is 9.40 ng/mL.
应用	ELISA FCM Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型	Human IgG1 kappa
推荐同型对照	Human IgG1 kappa, Isotype Control

偶联与修饰

偶联	Unconjugated

抗原信息

化学信息

分子量	145.85 kDa
CAS No.	1612838-76-2

储存&溶解度

存储	-20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Risankizumab