Name: PACAP (1-38), human, ovine, rat TFA
Brand: TargetMol
SKU: TP1054
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 1,470

待询

5 mg

¥ 4,350

待询

生物活性

产品描述	PACAP (1-38), human, ovine, rat TFA is an endogenous neuropeptide and a high-affinity agonist for the PAC1 receptor. This 38-amino acid peptide binds to the PAC1 receptor to activate adenylate cyclase, inducing an increase in intracellular cAMP levels and triggering downstream signaling. Research demonstrates that C-terminal amidation of PACAP (1-38), human, ovine, rat TFA is dispensable for its biological activity at the PAC1 receptor, with the non-amidated form retaining full agonistic potency. It plays crucial roles in neuroprotection, regulation of insulin secretion, and vasodilation.
体外活性	在表达人 PAC1 受体的 HEK293 细胞中，PACAP (1-38), human, ovine, rat TFA 强效诱导 cAMP 产生，其酰胺化与非酰胺化形式效力相似 [1]。在神经元培养中，该多肽通过激活 PAC1 介导的信号传导，促进神经突触生长并增强神经元存活 [1]。
别名	Pituitary Adenylate Cyclase Activating Polypeptide 38 TFA, Pituitary Adenylate Cyclase Activating Polypeptide 38 (TFA), PACAP (1-38), 人/羊/大鼠，三氟乙酸盐

化学信息

分子量	4648.28
分子式	C₂₀₃H₃₃₁N₆₃O₅₃S.C₂HF₃O₂
Smiles	[H]N[C@@H](CC1=CN=CN1)C(N[C@H](C(N[C@@H](CC(O)=O)C(NCC(N[C@]([H])(C(N[C@@H](CC2=CC=CC=C2)C(N[C@]([H])(C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@H](C(N[C@@H](C)C(N[C@@H](C)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCCCN)=O)CC(N)=O)=O)CCCCN)=O)C(C)C)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCCN)=O)=O)CCCNC(N)=N)=O)CCCCN)=O)=O)CC(C)C)=O)C(C)C)=O)=O)=O)CC(C)C)=O)=O)CCCCN)=O)CCCCN)=O)C(C)C)=O)=O)=O)CCC(N)=O)=O)CCCCN)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CO)=O)=O)CO)=O)=O)[C@H](O)C)=O)=O)[C@@H](C)CC)=O)=O)=O)CO)=O
密度	no data available
Sequence	His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
Sequence Short	HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK-NH2

储存&溶解度

存储	keep away from moisture \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	H2O: Soluble, Sonication is recommended.

PACAP (1-38), human, ovine, rat TFA