Cyclosporin E (11-Demethylcyclosporin A) is a cyclic oligopeptide isolated from imperfect fungi such as Trichoderma polysporum and is a member of the Cyclosporins family. It is valuable for investigating the structure-activity relationships and molecular dynamics of cyclosporin compounds. Cyclosporin E serves as a structural reference compound with significant research importance in medicinal chemistry and biophysics.