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Anti-Tyrosine Hydroxylase Antibody (4U295)
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产品编号 TMAY-03508
别名 tyrosine hydroxylase
Anti-Tyrosine Hydroxylase Antibody (4U295) 是一种 Rabbit 抗体，靶向 Tyrosine Hydroxylase。Anti-Tyrosine Hydroxylase Antibody (4U295) 可用于 WB,ELISA。
Anti-Tyrosine Hydroxylase Antibody (4U295)
Anti-Tyrosine Hydroxylase Antibody (4U295)
还可以产品编号 TMAY-03508 别名 tyrosine hydroxylase
Anti-Tyrosine Hydroxylase Antibody (4U295) 是一种 Rabbit 抗体，靶向 Tyrosine Hydroxylase。Anti-Tyrosine Hydroxylase Antibody (4U295) 可用于 WB,ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 2,279 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-Tyrosine Hydroxylase Antibody (4U295) is a Rabbit antibody targeting Tyrosine Hydroxylase. Anti-Tyrosine Hydroxylase Antibody (4U295) can be used in WB,ELISA. |
| 别名 | tyrosine hydroxylase |
| Ig Type | Rabbit IgG |
| 克隆号 | 4U295 |
| 交叉反应 | Mouse |
| 验证活性 | Anti-TH rabbit monoclonal antibody at 1:500 dilution. -Lane A: PC12 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:58 kDa. -Observed band size:63 kDa |
| 应用 | |
| 推荐剂量 | WB: 1:500-1:2000; ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TH / Tyrosine Hydroxylase (TMPY-02587; P24529; Pro2-Ser498). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Tyrosine hydroxylase (TH) is a rate-limiting enzyme in catecholamine synthesis. Tyrosine hydroxylase activity is modulated by protein-protein interactions with enzymes in the same pathway or the tetrahydrobiopterin pathway, structural proteins considered to be chaperones that mediate the neuron's oxidative state, and the protein that transfers dopamine into secretory vesicles. It is phosphorylated at serine (Ser) residues Ser8, Ser19, Ser31 and Ser40 in vitro. The phosphorylation of tyrosine hydroxylase at Ser19 or Ser8 has no direct effect on tyrosine hydroxylase activity. As tyrosine hydroxylase (TH) catalyses the formation of L-DOPA, the rate-limiting step in the biosynthesis of DA, the Parkinson's disease (PD) can be considered as a TH-deficiency syndrome of the striatum. A direct pathogenetic role of TH has also been suggested, as the enzyme is a source of reactive oxygen species (ROS) in vitro and a target for radical-mediated oxidative injury. Recently, it has been demonstrated that L-DOPA is effectively oxidized by mammalian Tyrosine hydroxylase in vitro, possibly contributing to the cytotoxic effects of DOPA. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Mouse TH / Tyrosine Hydroxylase protein (TMPY-02587) |
| 抗原种属 | Mouse |
| 研究领域 | Neurotransmitter Associated Enzymes |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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