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Anti-TREX1 Antibody (9A314)
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产品编号 TMAC-04114
别名 TREX1, Three-prime repair exonuclease 1, Deoxyribonuclease III (DNase III), 3'-5' exonuclease TREX1
Anti-TREX1 Antibody (9A314) 是一种 Rabbit 抗体，靶向 TREX1。Anti-TREX1 Antibody (9A314) 可用于 WB,ICC,IF,IHC。
Anti-TREX1 Antibody (9A314)
Anti-TREX1 Antibody (9A314)
还可以产品编号 TMAC-04114 别名 TREX1, Three-prime repair exonuclease 1, Deoxyribonuclease III (DNase III), 3'-5' exonuclease TREX1
Anti-TREX1 Antibody (9A314) 是一种 Rabbit 抗体，靶向 TREX1。Anti-TREX1 Antibody (9A314) 可用于 WB,ICC,IF,IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,495 | 5日内发货 | |
| 100 μL | ¥ 2,495 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-TREX1 Antibody (9A314) is a Rabbit antibody targeting TREX1. Anti-TREX1 Antibody (9A314) can be used in WB,ICC,IF,IHC. |
| 别名 | TREX1, Three-prime repair exonuclease 1, Deoxyribonuclease III (DNase III), 3'-5' exonuclease TREX1 |
| Ig Type | IgG |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of TREX1 on different cell lysates using anti-TREX1 at 1/500 dilution. Positive control: Line 1: A431, Line 2: SK-Br-3. 2. Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-TREX1 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue using anti-TREX1 antibody. Counter stained with hematoxylin. 4. ICC staining TREX1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining TREX1 in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining TREX1 in SiHa cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000; IHC: 1:50-200; ICC: 1:50-200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: human TREX1 aa 100-300 |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Theoretical: 34 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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