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顶部生物活性储存和溶解信息计算器

Anti-TIGIT Antibody (8K504)

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产品编号 TMAY-01330

别名 Vstm3, T cell immunoreceptor with Ig and ITIM domains, ENSMUSG00000071552

Anti-TIGIT Antibody (8K504) 是一种 Rabbit 抗体，靶向 TIGIT。Anti-TIGIT Antibody (8K504) 可用于 ELISA。

Anti-TIGIT Antibody (8K504)

Anti-TIGIT Antibody (8K504)

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产品编号 TMAY-01330 别名 Vstm3, T cell immunoreceptor with Ig and ITIM domains, ENSMUSG00000071552

Anti-TIGIT Antibody (8K504) 是一种 Rabbit 抗体，靶向 TIGIT。Anti-TIGIT Antibody (8K504) 可用于 ELISA。

规格价格库存数量
100 μL
¥ 1,679
5日内发货
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产品介绍

生物活性
产品描述
Anti-TIGIT Antibody (8K504) is a Rabbit antibody targeting TIGIT. Anti-TIGIT Antibody (8K504) can be used in ELISA.
别名Vstm3, T cell immunoreceptor with Ig and ITIM domains, ENSMUSG00000071552
Ig Type
Rabbit IgG
克隆号
8K504
交叉反应
Human
特异性
Human TIGIT
应用ELISA
推荐剂量
ELISA: 1:5000-1:10000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human TIGIT (rh TIGIT; NP_776160.2Met1-Phe138).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on regulatory, memory, activated T cells and NK cells. It binds PVR with high affinity, and PVRL2 with lower affinity, but not PVRL3. Knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses, however, TIGIT inhibits NK cytotoxicity directly through its ITIM. TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. The binding of PVR to TIGIT on human dendritic cells enhanced the production of IL-1 and diminished the production of IL-12p4. Also, TIGIT counter inhibits the NK-mediated killing of tumor cells and protects normal cells from NK-mediated cytotoxicity thus providing an "alternative self" mechanism for MHC class I inhibition.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint TargetsImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human TIGIT Protein
抗原种属
Human
研究领域
ITIM/ITAM Immunoreceptors and Related Molecules, Cancer Drug Targets
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

计算器

  • 稀释 计算器

关键词

ENSMUSG-00000071552ENSMUSG 00000071552

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