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Anti-TIGIT Antibody (8K504)
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产品编号 TMAY-01330
别名 Vstm3, T cell immunoreceptor with Ig and ITIM domains, ENSMUSG00000071552
Anti-TIGIT Antibody (8K504) 是一种 Rabbit 抗体，靶向 TIGIT。Anti-TIGIT Antibody (8K504) 可用于 ELISA。
Anti-TIGIT Antibody (8K504)
331 Anti-TIGIT Antibody (8K504)
还可以产品编号 TMAY-01330 别名 Vstm3, T cell immunoreceptor with Ig and ITIM domains, ENSMUSG00000071552
Anti-TIGIT Antibody (8K504) 是一种 Rabbit 抗体，靶向 TIGIT。Anti-TIGIT Antibody (8K504) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,679 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-TIGIT Antibody (8K504) is a Rabbit antibody targeting TIGIT. Anti-TIGIT Antibody (8K504) can be used in ELISA. |
| 别名 | Vstm3, T cell immunoreceptor with Ig and ITIM domains, ENSMUSG00000071552 |
| Ig Type | Rabbit IgG |
| 克隆号 | 8K504 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human TIGIT (rh TIGIT; NP_776160.2Met1-Phe138). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on regulatory, memory, activated T cells and NK cells. It binds PVR with high affinity, and PVRL2 with lower affinity, but not PVRL3. Knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses, however, TIGIT inhibits NK cytotoxicity directly through its ITIM. TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. The binding of PVR to TIGIT on human dendritic cells enhanced the production of IL-1 and diminished the production of IL-12p4. Also, TIGIT counter inhibits the NK-mediated killing of tumor cells and protects normal cells from NK-mediated cytotoxicity thus providing an "alternative self" mechanism for MHC class I inhibition.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human TIGIT Protein |
| 抗原种属 | Human |
| 研究领域 | ITIM/ITAM Immunoreceptors and Related Molecules, Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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