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Anti-SRPK1 Antibody (4L609)
还可以产品编号 TMAY-02298
别名 SRSF protein kinase 1, SFRSK1, RP3-422H11.1
Anti-SRPK1 Antibody (4L609) 是一种 Mouse 抗体，靶向 SRPK1。Anti-SRPK1 Antibody (4L609) 可用于 IHC-P。
Anti-SRPK1 Antibody (4L609)
Anti-SRPK1 Antibody (4L609)
还可以产品编号 TMAY-02298 别名 SRSF protein kinase 1, SFRSK1, RP3-422H11.1
Anti-SRPK1 Antibody (4L609) 是一种 Mouse 抗体，靶向 SRPK1。Anti-SRPK1 Antibody (4L609) 可用于 IHC-P。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,694 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-SRPK1 Antibody (4L609) is a Mouse antibody targeting SRPK1. Anti-SRPK1 Antibody (4L609) can be used in IHC-P. |
| 别名 | SRSF protein kinase 1, SFRSK1, RP3-422H11.1 |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4L609 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human SRPK1 in human testis with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human SRPK1 in human rectum with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SRPK1 (rh SRPK1; TMPY-04567; AAH38292.1; Glu2-Ser655). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Serine / threonine-protein kinase SRPK1, also known as SFRS protein kinase 1, Serine/arginine-rich protein-specific kinase 1, SR-protein-specific kinase 1 and SRPK1, is a cytoplasm and nucleus protein that belongs to the protein kinase superfamily and CMGC Ser/Thr protein kinase family. Isoform 2 of SRPK1 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 of SRPK1 is only seen in the testis, at lower levels than isoform 2. SRPK1 hyperphosphorylates RS domain-containing proteins such as SFRS1, SFRS2 and ZRSR2 on serine residues during metaphase but at lower levels during interphase. SRPK1 plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. SRPK1 locks onto SFRS1 to form a stable complex and processively phosphorylates the RS domain. SRPK1 appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human SRPK1 Protein (TMPY-04567) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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