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顶部生物活性储存和溶解信息计算器

Anti-SKA3 Antibody (3K426)

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Anti-SKA3 Antibody (3K426)
产品编号 TMAC-03767
别名 Spindle and kinetochore-associated protein 3, Spindle and kinetochore associated complex subunit 3, SKA 3, RAMA1, C13orf3

Anti-SKA3 Antibody (3K426) 是一种 Mouse 抗体，靶向 SKA3。Anti-SKA3 Antibody (3K426) 可用于 WB,IP,IF。

Anti-SKA3 Antibody (3K426)

Anti-SKA3 Antibody (3K426)

Rating icon 还可以
Anti-SKA3 Antibody (3K426)
产品编号 TMAC-03767 别名 Spindle and kinetochore-associated protein 3, Spindle and kinetochore associated complex subunit 3, SKA 3, RAMA1, C13orf3

Anti-SKA3 Antibody (3K426) 是一种 Mouse 抗体，靶向 SKA3。Anti-SKA3 Antibody (3K426) 可用于 WB,IP,IF。

规格价格库存数量
50 μL
¥ 1,980
5日内发货
100 μL
¥ 2,990
5日内发货
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产品介绍

生物活性
产品描述
Anti-SKA3 Antibody (3K426) is a Mouse antibody targeting SKA3. Anti-SKA3 Antibody (3K426) can be used in WB,IP,IF.
别名Spindle and kinetochore-associated protein 3, Spindle and kinetochore associated complex subunit 3, SKA 3, RAMA1, C13orf3
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of Ska3 expression in non-transfected (A) and human Ska3 transfected (B) 293T whole cell lysates.
应用
WB
IP
IF
推荐剂量
WB: 1:100-1000; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Ska3, also designated C13orf3 or RAMA1, is a 412 amino acid protein that belongs to the RAMA1 family of proteins. A component of the SKA1 complex, Ska3 localizes to the outer kinetochore and spindle microtubules during mito- sis. The SKA1 complex is a microtubule-binding subcomplex of the outer kine- tochore and is composed of two Ska1-Ska2 heterodimers, each heterodimer interacting with a Ska3 homodimer . Within the complex, which is important for chromosome segregation and facilitates microsphere movement along microtubules, Ska3 acts as a mediator of microtubule-stimulated oligomeriza- tion. The gene encoding for Ska3 maps to chromosome 13. Comprising nearly 4% of human DNA, chromosome 13 contains around 114 million base pairs and 400 genes. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. RB1 encodes a crucial tumor suppressor protein which, when defective, leads to malignant growth in the retina and has been implicated in a variety of other cancers. The gene SLITRK1, which is associated with Tourette syndrome, is on chromosome 13. As with most chromosomes, polysomy of part or all of chro- mosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is quite deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Amino acids 154-166 within an internal region of Ska3 of human origin
抗原种属
human
Uniprot ID
Q8IX90
化学信息
分子量Theoretical: 46 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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