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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-SARM1 Polyclonal Antibody

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货号 TMAB-12507

Anti-SARM1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 SARM1。Anti-SARM1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-SARM1 Polyclonal Antibody

Anti-SARM1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-12507

Anti-SARM1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 SARM1。Anti-SARM1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-SARM1 Polyclonal Antibody is a Rabbit antibody targeting SARM1. Anti-SARM1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:50-200
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm.
组织特异性Predominantly expressed in kidney and liver. Expressed at lower level in placenta.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景SARM, also known as SAMD2, SARM1 or KIAA0524, is a 724 amino acid protein that localizes to the cytoplasm and contains one TIR domain and two sterile alpha motif (SAM) domains. Expressed predominately in liver and kidney and present at lower levels in placenta, SARM interacts with TICAM-1 and, via this interaction, blocks the transcriptional activation activity of TICAM-1 and functions as a negative regulator of Toll-like receptor signaling. Additionally, SARM is thought to be involved in innate immune responses and may also play a role in the negative regulation of NFⅹB activation. SARM exists as two alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 17.
抗原信息
免疫原
KLH conjugated synthetic peptide: human SARM1
抗原种属
Human
基因名称
SARM1
基因ID
23098
蛋白名称
NAD(+) hydrolase SARM1
Uniprot ID
Q6SZW1
功能
Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.
化学信息
分子量Theoretical: 80 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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