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Anti-RP105/CD180 Antibody (7P240) 是一种 Rabbit 抗体,靶向 RP105/CD180。Anti-RP105/CD180 Antibody (7P240) 可用于 ELISA,IHC-P。
Anti-RP105/CD180 Antibody (7P240) 是一种 Rabbit 抗体,靶向 RP105/CD180。Anti-RP105/CD180 Antibody (7P240) 可用于 ELISA,IHC-P。
产品描述 | Anti-RP105/CD180 Antibody (7P240) is a Rabbit antibody targeting RP105/CD180. Anti-RP105/CD180 Antibody (7P240) can be used in ELISA,IHC-P. |
Ig Type | Monoclonal Rabbit IgG |
克隆号 | 7P240 |
交叉反应 | Mouse |
验证活性 | 1. Immunochemical staining of mouse CD180 in mouse thymus with rabbit monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of mouse CD180 in mouse spleen with rabbit monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). |
应用 | ELISA,IHC-P |
推荐剂量 | ELISA: 1:5000-1:10000; IHC-P: 1:50-1:200 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD180 / RP105 (rM CD180 / RP105; TMPY-01667; NP_032559.2; Met1-Ser626). |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD180, also known as RP105, is a B-cell surface molecule belonging to the family of pathogen receptors, Toll-like receptors (TLR). CD180 has an extracellular leucine-rich repeats and a short cytoplasmic tail. CD180 / RP105 interacts with an extracellular molecule named MD1 and then together form the cell surface receptor complex RP105 / MD1 which induces B-cell activation in humans and mice, leading to proliferation and up-regulation of a costimulatory molecule, B7.2 / CD86. CD180 / RP105 also has a role in LPS response because B cells lacking RP105 show hyporesponsiveness to LPS. |
偶联 | Unconjugated |
免疫原 | Recombinant Mouse CD180 / RP105 Protein (TMPY-01667) |
抗原种属 | Mouse |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
运输方式 | Shipping with blue ice. |
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