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顶部生物活性储存和溶解信息计算器

Anti-PTPN11 Antibody (1T267)

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Anti-PTPN11 Antibody (1T267)
产品编号 TMAC-03749
别名 SH-PTP 3, Shp2)

Anti-PTPN11 Antibody (1T267) 是一种 Rabbit 抗体，靶向 PTPN11。Anti-PTPN11 Antibody (1T267) 可用于 WB,ICC/IF,IHC,IP。

Anti-PTPN11 Antibody (1T267)

Anti-PTPN11 Antibody (1T267)

Rating icon 还可以
Anti-PTPN11 Antibody (1T267)
产品编号 TMAC-03749 别名 SH-PTP 3, Shp2)

Anti-PTPN11 Antibody (1T267) 是一种 Rabbit 抗体，靶向 PTPN11。Anti-PTPN11 Antibody (1T267) 可用于 WB,ICC/IF,IHC,IP。

规格价格库存数量
50 μL
¥ 1,485
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100 μL
¥ 2,490
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产品介绍

生物活性
产品描述
Anti-PTPN11 Antibody (1T267) is a Rabbit antibody targeting PTPN11. Anti-PTPN11 Antibody (1T267) can be used in WB,ICC/IF,IHC,IP.
别名SH-PTP 3, Shp2)
Ig Type
IgG
交叉反应
Human
验证活性
1. Western blot analysis of SHP2 on different lysates using anti-SHP2 antibody at 1/1,000 dilution. Positive control: Lane 1: Hela, Lane 2: 293.
2. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-SHP2 antibody. Counter stained with hematoxylin.
3. ICC staining SHP2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
4. ICC staining SHP2 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
5. ICC staining SHP2 in NIH/3T3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
应用
WB
ICC/IF
IHC
IP
推荐剂量
WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. SH2 domains generally mediate the association of regulatory molecules with specific phosphotyrosine-containing sites on autophosphorylated receptors, thereby controlling the initial interaction of receptors with these substrates. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified. Strong sequence similarity between SH-PTP2 and the Drosophila gene corkscrew (CSW) and their similar patterns of expression suggest that SH-PTP2 is the human corkscrew homolog.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
Q06124
化学信息
分子量Theoretical: 70 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

Tyrosine-protein phosphatase non-receptor type 11SH-PTP3SH-PTP2 (SHP-2SH-PTP2 (SHP2SHPTP2SHPTP 2Shp 2)PTPN11PTPN 11PTP-2CPTP2CPTP-1DPTP1DProtein-tyrosine phosphatase 2C (PTP-2C)Protein-tyrosine phosphatase 1D (PTP-1D)

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4个月前
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