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Anti-Phospho-STK11 (Ser428) Polyclonal Antibody

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Anti-Phospho-STK11 (Ser428) Polyclonal Antibody
产品编号 TMAC-02409
别名 STK11 (p-Ser428), STK11 (p-S428), p-STK11 (Ser428), p-STK11 (S428)

Anti-Phospho-STK11 (Ser428) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-STK11 (Ser428)。Anti-Phospho-STK11 (Ser428) Polyclonal Antibody 可用于 WB。

Anti-Phospho-STK11 (Ser428) Polyclonal Antibody

Anti-Phospho-STK11 (Ser428) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-STK11 (Ser428) Polyclonal Antibody
产品编号 TMAC-02409 别名 STK11 (p-Ser428), STK11 (p-S428), p-STK11 (Ser428), p-STK11 (S428)

Anti-Phospho-STK11 (Ser428) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-STK11 (Ser428)。Anti-Phospho-STK11 (Ser428) Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,485
5日内发货
100 μL
¥ 2,230
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-STK11 (Ser428) Polyclonal Antibody is a Rabbit antibody targeting Phospho-STK11 (Ser428). Anti-Phospho-STK11 (Ser428) Polyclonal Antibody can be used in WB.
别名STK11 (p-Ser428), STK11 (p-S428), p-STK11 (Ser428), p-STK11 (S428)
Ig Type
IgG
交叉反应
Human
验证活性
1. Western blot analysis of extracts from HeLa cells treated with PMA using Phospho-LKB1 (Ser428) antibody TMAC-02409. The lane on the right is treated with the antigen-specific peptide.
应用
WB
推荐剂量
WB: 1:500-1000
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2: it thereby regulates inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neurons polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1 Also acts as a mediator p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of serine428 (R-L-S(p)-A-C) derived from Human LKB1
抗原种属
human
Uniprot ID
Q15831
化学信息
分子量Actual: 65 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

STK11 (pSer428)STK11 (pS428)STK11 (phospho-Ser428)STK11 (phospho-S428)pSTK11 (Ser428)pSTK11 (S428)

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